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The upcoming NFL clash on November 30, 2025, between the Buffalo Bills and Pittsburgh Steelers at Acrisure Stadium in Pittsburgh, PA, promises an exciting Sunday football showdown broadcasted on CBS. This game offers intriguing betting opportunities as our picks suggest the Buffalo Bills will edge out the Steelers with a predicted score of 25-21, covering a spread of Buffalo Bills -4.5. Our prediction model has been profitable in recent games, boasting a strong hit rate on 2-way bets with high expected value, making these picks especially valuable for bettors looking for smart betting tips.
Buffalo Bills vs Pittsburgh Steelers is a must-watch for NFL fans and bettors alike. The total points are predicted to stay under 47, aligning with our American Total market insights that have shown a consistent cover percentage of 52.2%. This data-driven approach helps bettors make informed decisions and maximize their potential returns. For more detailed NFL picks and expert analysis, check out our comprehensive NFL picks page.
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Detroit 7-439% -2½ -114Caesars | |||||||
Dallas 5-5-148% +3½ -118BetRivers | |||||||
![]() Baltimore 6-516% -6½ -115Bet365 | |||||||
Philadelphia 8-340% -6½ -125BetMGM | |||||||
![]() Indianapolis 8-334% -3½ -110Bet365 | |||||||
![]() Tampa Bay 6-545% -2½ -115Bet365 | |||||||
![]() Tennessee 1-1087% +6½ -105BetMGM | |||||||
Carolina 6-6- +10½ -109BetRivers | |||||||
Miami 4-712% -5½ -112BetRivers | |||||||
![]() N.Y. Jets 2-980% +2½ -105BetMGM | |||||||
Cleveland 3-840% +6½ -122FanDuel | |||||||
Seattle 8-322% -10½ -105Bet365 | |||||||
![]() Pittsburgh 6-581% +4½ -115BetRivers | |||||||
![]() L.A. Chargers 7-420% -9½ -110Bet365 | |||||||
![]() Washington 3-887% +6½ -102BetMGM | |||||||
New England 10-220% -7½ -105Caesars |
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