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The upcoming NFL showdown on December 28, 2025, between the Chicago Bears and San Francisco 49ers at Levi's Stadium in Santa Clara, CA, is set to be a thrilling Sunday night football event. This regular season Week 17 game will be broadcast on NBC and NBC Peacock, giving fans an exciting opportunity to catch all the action live.
Injury report updates are crucial for bettors looking to make smart wagers. The Chicago Bears are dealing with several injuries including linebacker Tremaine Edmunds, who has been moved to injured reserve due to a groin injury, and tight end Cole Kmet, who is questionable with an ankle issue. Running backs Travis Homer and D'Andre Swift are also questionable, impacting the Bears' offensive strategies. Defensive line Andrew Billings is recovering from surgery, though he is participating fully in practice. Wide receivers Rome Odunze and Luther Burden III are both out, affecting the Bears' receiving options.
For the San Francisco 49ers, running back Christian McCaffrey is questionable but expected to play despite a calf injury. Offensive tackle Trent Williams is questionable as well, while defensive line Yetur Gross-Matos remains questionable and will not return from injured reserve this season. Other key players like linebacker Nick Martin are out due to concussion protocols, and wide receiver Ricky Pearsall is out with a knee issue. These injury statuses could significantly influence the game's dynamics and betting lines.
Keeping an eye on the injury list helps bettors understand potential lineup changes and game flow, enabling more informed wagers. For comprehensive details, check out the NFL injury report page. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
![]() Washington 4-1160% +7 -120BetRivers | |||||||
Minnesota 7-866% +6 -110Bet365 | |||||||
![]() Kansas City 6-973% +13 -110Bet365 | |||||||
![]() L.A. Chargers 11-448% -1½ -112BetRivers | |||||||
Green Bay 9-5-142% -2½ -105FanDuel | |||||||
![]() Cincinnati 5-1011% -7 -108BetRivers | |||||||
Carolina 8-764% +7½ -120FanDuel | |||||||
Cleveland 3-1282% +4 -108BetRivers | |||||||
![]() Tennessee 3-1265% +3 -118FanDuel | |||||||
Miami 6-994% +5½ -110Bet365 | |||||||
![]() Indianapolis 8-7- +6½ -104FanDuel | |||||||
![]() N.Y. Jets 3-12100% +13½ -110Bet365 | |||||||
![]() Las Vegas 2-1350% -1 -105BetMGM | |||||||
Buffalo 11-433% -2 -112Caesars | |||||||
![]() San Francisco 11-4100% -2½ -120BetRivers | |||||||
![]() Atlanta 6-987% +8½ -115Caesars |
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