Betting Trends Kansas City Chiefs vs Denver Broncos

The upcoming NFL clash on November 16, 2025, between the Kansas City Chiefs and Denver Broncos at Empower Field at Mile High in Denver, CO, promises an exciting Sunday football showdown. The Chiefs, led by star quarterback Patrick Mahomes, will face off against the Broncos' Bo Nix in a game that will test the strengths of both teams' offenses and defenses. Kansas City boasts a potent pass offense averaging 248.9 yards per game, while Denver's pass defense holds opponents to just 179.5 yards, setting the stage for a thrilling aerial battle.

Denver's run offense, averaging 128.6 yards per game, faces a tough test against Kansas City's run defense, which limits opponents to 104.6 yards. Pass protection will be critical as Kansas City's offensive line contends with Denver's aggressive pass rush, which averages 6.6 sacks per game. Meanwhile, the Chiefs' defense must contain Denver's balanced attack, which combines solid passing and rushing stats.

Injuries could influence the game, with Denver missing key players like J.K. Dobbins and Pat Surtain II, while Kansas City will be without running back Isiah Pacheco. The Chiefs are favored by 4 points with a total points line set at 45, indicating expectations of a moderately high-scoring contest. The best odds for Kansas City are -108 at Caesars, while Denver is +4 at -113 at the same sportsbook.

This matchup follows a dominant Denver Broncos 38-0 win over the Chiefs on January 5, 2025, a game that saw Denver control the pace and defense effectively. The Chiefs have a 5-4 straight-up record and a 5-4 against-the-spread record this season, while Denver holds an 8-2 straight-up record but struggles 4-6 ATS. These betting trends and game insights provide valuable information for bettors looking to make smart wagers.

Tune in to CBS on November 16 to catch all the action live. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.