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Before the big showdown in NFL's Week 5, the New York Giants are set to face the New Orleans Saints on October 5, 2025, at the Caesars Superdome in New Orleans, LA. This game promises an electrifying clash as both teams aim to gain momentum in the season. Our picks suggest the Giants have a slight edge with a predicted score of 21-20 over the Saints. Tune in to CBS for live coverage and place your bets wisely with our predictions.
Our prediction model indicates a profitable edge for bettors, with the Giants covering the spread at a 56.6% hit rate, offering a solid EV of 3.4%. Historically, our predictions have been reliable, with our picks covering 6 out of the last 10 games. We advise considering the Giants' spread for a strategic bet.
For more NFL predictions and to gain an edge in your sports betting, check out our NFL picks page. Ready to elevate your betting game? Start your OddsTrader Turbo subscription today or place your bet with a U.S. regulated sportsbook.
![]() L.A. Rams 3-154% -5½ -105FanDuel | |||||||
Cleveland 1-342% +3½ -109BetRivers | |||||||
Carolina 1-3100% +1½ -108Caesars | |||||||
![]() N.Y. Jets 0-4- +2½ +100Bet365 | |||||||
![]() Indianapolis 3-123% -6½ -110Bet365 | |||||||
Philadelphia 4-00% -4½ -105Caesars | |||||||
New Orleans 0-447% +1 -125BetMGM | |||||||
![]() Baltimore 1-319% -3½ +108Caesars | |||||||
Arizona 2-241% -8½ -110Bet365 | |||||||
Seattle 3-160% -3 -115BetRivers | |||||||
![]() Cincinnati 2-2- +9½ -105Bet365 | |||||||
![]() L.A. Chargers 3-142% -2½ -118BetMGM | |||||||
Buffalo 4-016% -7½ -110Caesars | |||||||
Jacksonville 3-181% +3½ -115Caesars |
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