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Jan 17, 2026 8:00 PM EST
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SEA
-7½ (-110)o45½ (-110)
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San Francisco 49ers vs Seattle Seahawks Picks
Updated:Jan 13, 2026 1:14 AM EST
The upcoming NFL clash on January 18, 2026, features the San Francisco 49ers visiting the Seattle Seahawks at Lumen Field in Seattle, WA. This Saturday football game promises intense action and strategic plays as both teams battle for supremacy in the 2025-26 NFL season.
Our expert picks for this San Francisco 49ers vs Seattle Seahawks matchup lean towards the Seahawks securing a victory with a predicted score of 27-21. The spread favors Seattle by 7.5 points, reflecting their strong betting odds. Additionally, the projected total score hovers around 48.3 points, with the under 46 bet showing a compelling expected value, making it a smart choice for bettors.
In recent games, our betting tips have demonstrated a solid hit rate and positive EV, especially in the American Total market, which has been profitable in the last 10 games. This track record provides confidence in our predictions for this game. The match will be broadcast on Fox, ensuring fans can catch all the live action.
For those looking to place wagers, the best odds for Seattle and San Francisco are available at trusted sportsbooks, which you can explore through our sportsbook reviews. To dive deeper into NFL picks and enhance your betting strategy, visit our comprehensive NFL picks and predictions page.
UPCOMING GAME PREDICTION
Spread
Money
Total
SFSpread
CONSENSUS LINE
+7½ (-110)
PROJECTION
SEA (27) - SF (21)
COVER PROBABILITY
EXPECTED VALUE
+2.7%
BET RATING
SEASON COVER %
12/18
67%
NFL
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This Week
Last Week
NFLDivision
 Denver 14-369% +1½ -115Bovada | |||||||
 Seattle 14-351% -7½ -103Heritage | |||||||
 New England 15-3100% -2½ -120BetOnline | |||||||
 Chicago 12-675% +4½ -108Heritage |
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