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The San Francisco 49ers are set to clash with the Seattle Seahawks on September 7, 2025, at Lumen Field in Seattle, WA. This NFL matchup promises to be thrilling as both teams kick off their 2025-26 season. Fans can expect a game filled with strategic plays and exciting game props, including touchdowns and field goals, broadcasted on Fox. The 49ers, known for their robust pass offense, will be up against the Seahawks' formidable pass defense. Meanwhile, Seattle's run offense will test San Francisco's run defense, making the game props particularly enticing. Our NFL player props page offers insights into prop bets with a high hit rate, especially in the team total points market. Historically, our projections have been spot-on for both teams, making this a must-watch and wager game. For those looking to make informed bets, our OddsTrader Turbo subscription provides an edge with meticulous game projections and prop bets. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
![]() Tennessee 0-274% +5 -110Bet365 | |||||||
Carolina 0-277% +5½ -115BetMGM | |||||||
![]() Washington 1-140% -3 +100Caesars | |||||||
Cleveland 0-281% +8½ -115BetMGM | |||||||
Minnesota 1-151% -3 -105BetMGM | |||||||
Philadelphia 2-044% -3 -125Caesars | |||||||
New England 1-162% +2 -112BetRivers | |||||||
![]() Tampa Bay 2-018% -6½ -110Caesars | |||||||
Jacksonville 1-162% -1½ -110Caesars | |||||||
![]() L.A. Chargers 2-031% -2½ -118BetRivers | |||||||
Seattle 1-118% -7 -110Bet365 | |||||||
![]() Chicago 0-284% +1½ -110FanDuel | |||||||
![]() San Francisco 2-047% -2 -109BetRivers | |||||||
![]() N.Y. Giants 0-277% +6 -105Caesars | |||||||
![]() Baltimore 1-130% -4½ -110Caesars | |||||||
Buffalo 3-031 -11 -110Bet365 |
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