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FINAL
Nov 16, 2025 4:05 PM EST
SF 41 vs ARI 22
Week 11
SF
-3½ (-104)o48½ (-108)
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Arizona Cardinals vs San Francisco 49ers Odds
Updated:Nov 16, 2025 1:37 AM EST
The upcoming NFL showdown on November 16, 2025, features the Arizona Cardinals vs San Francisco 49ers at State Farm Stadium in Glendale, AZ. This Sunday football game is set to be a thrilling Week 11 matchup broadcasted on FOX. Bettors will find key insights in the odds and betting lines that can help shape smart wagering decisions.
Currently, the San Francisco 49ers are favored with a point spread of -3½ -112, while the Arizona Cardinals hold the underdog position at +3½ -110. Opening odds showed a similar spread, indicating steady confidence in the 49ers maintaining their edge. The moneyline favors San Francisco at -190 versus Arizona at +156, reflecting the general expectations of the game outcome. Total points are set at 48½ with the under favored at -112, suggesting a potentially defensive battle.
Understanding these odds and how they've moved from opening to current figures is crucial for bettors aiming to capitalize on market shifts. The venue's retractable dome at State Farm Stadium could influence game conditions, adding another layer to consider. For comprehensive NFL betting lines and more detailed odds, check out the NFL odds page.
Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge. The best odds today for San Francisco 49ers is -3½ -112 at Caesars and for Arizona Cardinals +3½ -110 at Caesars.
Spread (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
San FranciscoSpread
+1.8%
EV
+1.8%
ArizonaSpread
-7.1%
EV
-7.1%
MONEYLINE (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
San FranciscoMONEYLINE
+0.6%
EV
+0.6%
ArizonaMONEYLINE
-4.1%
EV
-4.1%
Total (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
OVERTotal
-9.9%
EV
-9.9%
UNDERTotal
+2.7%
EV
+2.7%
Spread (1H)
BEST LINE
San FranciscoSpread
ArizonaSpread
MONEYLINE (1H)
BEST LINE
San FranciscoMONEYLINE
ArizonaMONEYLINE
Total (1H)
BEST LINE
OVERTotal
UNDERTotal
Spread (2H)
BEST LINE
San FranciscoSpread
ArizonaSpread
MONEYLINE (2H)
BEST LINE
San FranciscoMONEYLINE
ArizonaMONEYLINE
Total (2H)
BEST LINE
OVERTotal
UNDERTotal
Spread (1Q)
BEST LINE
San FranciscoSpread
ArizonaSpread
MONEYLINE (1Q)
BEST LINE
San FranciscoMONEYLINE
ArizonaMONEYLINE
Total (1Q)
BEST LINE
OVERTotal
UNDERTotal
Spread (2Q)
BEST LINE
San FranciscoSpread
ArizonaSpread
MONEYLINE (2Q)
BEST LINE
San FranciscoMONEYLINE
ArizonaMONEYLINE
Total (2Q)
BEST LINE
OVERTotal
UNDERTotal
Spread (3Q)
BEST LINE
San FranciscoSpread
ArizonaSpread
MONEYLINE (3Q)
BEST LINE
San FranciscoMONEYLINE
ArizonaMONEYLINE
Total (3Q)
BEST LINE
OVERTotal
UNDERTotal
Spread (4Q)
BEST LINE
San FranciscoSpread
ArizonaSpread
MONEYLINE (4Q)
BEST LINE
San FranciscoMONEYLINE
ArizonaMONEYLINE
Total (4Q)
BEST LINE
OVERTotal
UNDERTotal
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