Player Props Arizona Cardinals vs San Francisco 49ers

The upcoming NFL showdown on November 16, 2025, between the Arizona Cardinals and San Francisco 49ers at State Farm Stadium in Glendale, AZ, is set to be a thrilling Sunday football event. Broadcast live on Fox, this game offers plenty of opportunities for bettors to capitalize on player props and prop bets.

When comparing the teams, the Cardinals' pass offense faces a challenging San Francisco pass defense, while the 49ers' pass protection is tested against Arizona's aggressive pass rush. The run offense versus run defense battle will be key, especially with San Francisco's Christian McCaffrey expected to have a big game, with a player prop for over 131.5 total rushing and receiving yards showing a strong 66.3% hit rate and 13.0% EV. This prop bet stands out as a high expected value opportunity for bettors.

Arizona's Budda Baker also presents a valuable player prop, with an over 6.5 tackles and assists bet boasting a 69.5% hit rate and 14.9% EV. Our player projections have been reliable, with our prop bet results in the last 10 games showing consistent profitability, especially in markets like rushing yards and receiving yards.

Understanding the pace of play and the matchups between pass offense and defense, as well as run offense and defense, can help bettors make smart decisions. For more detailed insights and to explore all NFL player props, check out our comprehensive NFL player props page. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.