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FINAL
Nov 16, 2025 4:05 PM EST
SF 41 vs ARI 22
Week 11
SF
-3½ (-104)o48½ (-108)
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Arizona Cardinals vs San Francisco 49ers Picks
Updated:Nov 16, 2025 1:41 AM EST
The upcoming Sunday football game on November 16, 2025, features a thrilling NFL matchup between the Arizona Cardinals and the San Francisco 49ers at State Farm Stadium in Glendale, AZ. This game is set to be broadcast on FOX, making it accessible for fans and bettors alike.
Our expert picks favor the San Francisco 49ers with a predicted score of 26 against the Cardinals' 21, and a spread of 49ers -3.5. The predicted total score is just under the posted total, suggesting a strategic bet on the under 48.5 points. This prediction aligns with our model's strong recent performance, which has seen a 53.2% cover rate on 49ers spreads and a compelling 55.4% hit rate with a positive EV on under total bets in the last 10 games.
These stats highlight the value of our betting tips and predictions for this game, guiding bettors to make informed decisions. For more NFL insights and to explore a wider range of picks, check out our comprehensive NFL picks and predictions. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit from the edge.
UPCOMING GAME PREDICTION
Spread
Money
Total
SFSpread
CONSENSUS LINE
-3½ (-109)
PROJECTION
SF (26) - ARI (21)
COVER PROBABILITY
EXPECTED VALUE
+1.8%
BET RATING
SEASON COVER %
5/10
50%
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