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The upcoming NFL game between the Buffalo Bills and the Detroit Lions at Ford Field in Detroit, MI, promises to be an exciting matchup. The game is scheduled for December 15, 2024, at 4:25 PM EST, and will be broadcast on CBS. The Lions, with a strong home record of 6-1, are favored with a -2.5 point spread, reflecting their impressive season standing at 12-1. The Bills, on the other hand, have a 10-3 record and have shown resilience on the road with a 4-3 away record, as seen on our NFL standings page. In their last matchup on November 24, 2022, the Bills narrowly defeated the Lions with a score of 28-25. This game is expected to be a high-scoring affair, with the total points line set at 54.5. Key players to watch include Josh Allen for the Bills, who has been pivotal in their offensive strategy, and Jared Goff for the Lions, leading a dynamic offense. With both teams having potent offenses, the game could hinge on defensive plays. The best bet for this game is to back the Lions at home given their formidable record this season.