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The Denver Broncos are set to face off against the San Francisco 49ers in their PRE Week 1 matchup on August 9, 2025, at Levi's Stadium in Santa Clara, CA. The game is scheduled for 8:30 PM ET and can be watched live on the NFL Network. The Broncos, with their starting quarterback Bo Nix, are favored with a point spread of -7, according to Caesars. The 49ers, led by Brock Purdy, will be looking to upset the odds and capitalize on their home advantage. NFL standings page. In their last matchup on August 19, 2023, the 49ers narrowly defeated the Broncos with a final score of 21-20. Both teams have been dealing with significant injuries, which could affect their performance in this game. The Broncos' linebacker Dre Greenlaw is questionable but likely to play, while the 49ers' Brandon Aiyuk is on the PUP list. This game promises to be an exciting encounter as both teams look to start their preseason on a high note. Betting enthusiasts should keep an eye on the point spread and injury reports to make informed decisions. The odds for the total points are set at 34.5, with the OVER favored at -110. The Broncos' recent performance against the spread and the 49ers' home advantage make this a must-watch game for football fans and bettors alike.