- Spread
- Money
- Total
- Merged
Personalize your notifications and get updates on the teams, players or events you care about most.
FINAL
Sep 14, 2025 1:00 PM EDT
SF 26 vs NO 21
Week 2
SF
-3 (-105)o40½ (-110)
FOXBETCAST
PLAYS
MATCHUP
PREDICTION
ODDS
PLAYER PROPS
GAME PROPS
INJURIES
WEATHER
CHAT
Event NotificationsStay on top of the action with alerts for game start, scoring, odds updates, predictions and more.
Don't show me this again
Odds for New Orleans Saints vs San Francisco 49ers
Updated:Sep 14, 2025 3:18 AM EDT
As we gear up for the NFL's regular season, the San Francisco 49ers are set to host the New Orleans Saints on September 14, 2025, at the Caesars Superdome in New Orleans, LA. This highly anticipated matchup promises to deliver thrilling Sunday football action, broadcasted on FOX. The 49ers, playing under the dome, are currently favored with a point spread of -3 -105, according to Caesars, while the Saints are the underdogs at +3 -115. The over/under is set at 40.5, with both sides priced at -110.
The key to understanding these odds lies in the 49ers' recent form, which has seen them rise as favorites. Bettors looking to capitalize on this game should consider the point spread as a strategic play. The Saints, though underdogs, have shown resilience in past encounters, making the moneyline of +135 at Caesars an intriguing option for those backing an upset.
For bettors seeking the best odds, Caesars offers competitive lines. Additionally, check the latest NFL odds for more insights. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook. This game is a must-watch for NFL enthusiasts eager to witness top-tier football action.
Spread (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
San FranciscoSpread
-2.6%
EV
-2.6%
New OrleansSpread
-0.7%
EV
-0.7%
MONEYLINE (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
San FranciscoMONEYLINE
-1.4%
EV
-1.4%
New OrleansMONEYLINE
-1.8%
EV
-1.8%
Total (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
OVERTotal
+0.6%
EV
+0.6%
UNDERTotal
+3.5%
EV
+3.5%
Spread (1H)
BEST LINE
San FranciscoSpread
New OrleansSpread
MONEYLINE (1H)
BEST LINE
San FranciscoMONEYLINE
New OrleansMONEYLINE
Total (1H)
BEST LINE
OVERTotal
UNDERTotal
Spread (2H)
BEST LINE
San FranciscoSpread
New OrleansSpread
MONEYLINE (2H)
BEST LINE
San FranciscoMONEYLINE
New OrleansMONEYLINE
Total (2H)
BEST LINE
OVERTotal
UNDERTotal
Spread (1Q)
BEST LINE
San FranciscoSpread
New OrleansSpread
MONEYLINE (1Q)
BEST LINE
San FranciscoMONEYLINE
New OrleansMONEYLINE
Total (1Q)
BEST LINE
OVERTotal
UNDERTotal
Spread (2Q)
BEST LINE
San FranciscoSpread
New OrleansSpread
MONEYLINE (2Q)
BEST LINE
San FranciscoMONEYLINE
New OrleansMONEYLINE
Total (2Q)
BEST LINE
OVERTotal
UNDERTotal
Spread (3Q)
BEST LINE
San FranciscoSpread
New OrleansSpread
MONEYLINE (3Q)
BEST LINE
San FranciscoMONEYLINE
New OrleansMONEYLINE
Total (3Q)
BEST LINE
OVERTotal
UNDERTotal
Spread (4Q)
BEST LINE
San FranciscoSpread
New OrleansSpread
MONEYLINE (4Q)
BEST LINE
San FranciscoMONEYLINE
New OrleansMONEYLINE
Total (4Q)
BEST LINE
OVERTotal
UNDERTotal
NFL
Spread
Game
- Game
- 1H
- 2H
- 1Q
- 2Q
- 3Q
- 4Q
NFLSuper Bowl
Download the app© OddsTrader 2026 All Rights Reserved
The content on this site is for entertainment purposes only. OddsTrader makes no representation or warranty as to the accuracy of the information given or the outcome of any game or event. Please be aware of and respect the laws regarding sports betting for your jurisdiction as they vary from state to state. OddsTrader does not target underaged persons. Using this information to contravene any law or statute is prohibited. This site contains commercial content, and OddsTrader may be compensated for the links provided on this site.Disclosure.
OddsTrader no longer operates under any U.S. license, including Pennsylvania.
Seek help with a gambling addiction at 1-800-Gambler.