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FINAL
Sep 14, 2025 1:00 PM EDT
SF 26 vs NO 21
Week 2
SF
-3 (-105)o40½ (-110)
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Betting Trends: 49ers vs Saints
Updated:Sep 14, 2025 3:52 AM EDT
The upcoming clash on September 14, 2025, between the San Francisco 49ers and the New Orleans Saints at Caesars Superdome in New Orleans promises an electrifying start to Week 2 of the NFL season. The Saints have struggled recently, losing their last matchup 20-13 against the Arizona Cardinals. With Trevor Penning out and Taysom Hill on PUP-R, the Saints' offensive line may face challenges against the 49ers' formidable pass rush led by Nick Bosa. Quarterback Spencer Rattler will need to step up, especially against San Francisco's strong pass defense.
On the other hand, the 49ers are coming off a win against the Seattle Seahawks, with a 17-13 victory. However, the absence of Brock Purdy due to a toe injury means Mac Jones will take the helm. The 49ers' offensive line, with Trent Williams questionable, will need to protect Jones against the Saints' defense, which has shown resilience despite recent losses.
Both teams have shown contrasting performances in recent games. The Saints' pass offense will be tested against the 49ers' pass defense, which has allowed only 146 passing yards in their last game. Meanwhile, the 49ers' run offense, led by Christian McCaffrey, aims to exploit the Saints' run defense. With a point spread of 49ers -3 and total points set at 40.5, bettors may find value in the 49ers covering the spread. For more detailed betting insights and to make an informed decision, consider Caesars.
ATS Records
All
12-7 (5th)Against the Spread9-8 (13th)
13-6 (8th)Straight Up6-11 (25th)
+5.5Straight Up Units-2.7
12-7Over / Under5-12
TEAM MATCHUP
OFF
DEF
OFF
DEF
25.7Points18
13.3First Half8.4
12.4Second Half9.7
5.6First Quarter1.7
7.7Second Quarter6.7
5.5Third Quarter3.8
6.8Fourth Quarter5.9
351.4Total Yards313.6
5.7Yards Per Play5.2
244.5Passing Yards219.3
23.4 - 33.8 (69.3%)Completions-Attempts23.4 - 34.8 (67.2%)
6.9Yards Per Passing Play5.8
1.6 (9)Sacks (Yards)2.9 (18)
106.9Rushing Yards94.3
28.3Attempts25.6
3.8Yards Per Rush3.7
22.31st Downs18.8
13.9Passing10.8
7Rushing5.9
1.4Penalties2.1
6.2 / 12.5 (49.8%)3rd Down5.2 / 13.1 (39.5%)
0.8 / 1.3 (59.1%)4th Down0.8 / 2 (41.2%)
2.5 / 3.9 (65.2%)Red Zone1.2 / 2.6 (44.4%)
4.9 (38.3)Penalties (Yards)6.9 (54.1)
0.7Turnovers1.3
0.4Interceptions0.6
0.4Fumbles Lost0.7
63.6Total Plays63.2
5.6Kickoffs4.5
3Returns3.9
81.5Return Yards97.9
27.2Yards Per Return25.2
2.6Punts3.4
1.5Returns1.4
17.1Return Yards12.9
11.6Yards Per Return9.1
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