Oct 12, 2025 1:00 PM EDT

Week 6

Arizona

4-1

Indianapolis

IND

-9 (-110)o46½ (-110)

FOX

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Arizona Cardinals vs Indianapolis Colts Betting Trends

Updated:Oct 12, 2025 2:19 AM EDT

Before the much-anticipated NFL showdown between the Arizona Cardinals and Indianapolis Colts on October 12, 2025, fans and bettors alike are gearing up for an electrifying Sunday football matchup at Lucas Oil Stadium in Indianapolis, IN. The Colts, boasting a strong home record of 3-0, are set to face the Cardinals, who have a 2-0 record against the spread as the away team. This game promises to be a thrilling encounter, especially with the Colts' Daniel Jones leading the charge as quarterback, while the Cardinals might have to rely on Jacoby Brissett due to Kyler Murray's questionable foot injury.

With the Colts showcasing a potent offensive lineup, averaging 381.2 total yards per game, they will look to exploit Arizona's defense, which gives up 346.6 yards per game. On the flip side, Arizona's passing offense, led by Brissett, will need to navigate Indianapolis' robust pass defense and find a way to outscore them. The betting trends suggest a close game, with the point spread favoring the Colts by 9.5 points, while the total points are set at 46.5. Considering past performances, the Colts' ability to score, coupled with their home advantage, makes them the favorites.

Fans can catch this exciting clash on FOX, making it a must-watch for those looking to place bets based on detailed sports insights. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

Who is favored to win the Arizona Cardinals vs Indianapolis Colts matchup?

ATS Records

Arizona

Indianapolis

All

All
1st half
2nd half
1st quarter
2nd quarter
3rd quarter
4th quarter

2-3 (24th)Against the Spread4-1 (1st)

2-3 (20th)Straight Up4-1 (3rd)

-2.4Straight Up Units+1.6

2-3Over / Under2-3

TEAM MATCHUP

Arizona

Indianapolis

OFF

DEF

OFF

DEF

20.6Points32.6

12.8First Half18

7.8Second Half14.6

6First Quarter5.8

6.8Second Quarter12.2

3.2Third Quarter8

4.6Fourth Quarter6.6

288.4Total Yards381.2

5.4Yards Per Play6.4

170.2Passing Yards253

22 - 32.4 (67.9%)Completions-Attempts21.6 - 30.6 (70.6%)

4.8Yards Per Passing Play8.1

3.2 (22)Sacks (Yards)0.8 (7)

118.2Rushing Yards128.2

24.6Attempts29.2

4.8Yards Per Rush4.4

171st Downs23.2

10Passing12.6

5.2Rushing7.8

1.8Penalties2.8

5.4 / 13.6 (39.7%)3rd Down5.4 / 11.6 (46.6%)

0.8 / 0.8 (100%)4th Down1.2 / 1.6 (75%)

2 / 3.4 (58.8%)Red Zone3 / 5 (60%)

8.2 (54.6)Penalties (Yards)7.8 (60.2)

1.2Turnovers1.4

0.6Interceptions1.2

0.6Fumbles Lost0.2

60.2Total Plays60.6

4.8Kickoffs6.6

4Returns3.2

98.2Return Yards87.2

24.6Yards Per Return27.3

4.4Punts1.4

1.6Returns0.8

19.6Return Yards7

12.3Yards Per Return8.8

Priority Injuries

Arizona

Indianapolis

PRIORITY

Kyler Murray

Questionable

Est. Return Oct 12, 2025

1 Quarterback

7 hours ago

PRIORITY

Trey Benson

Injury Reserve

Est. Return Nov 9, 2025

33 Running Back

11 days ago

PRIORITY

James Conner

Injury Reserve

Est. Return Feb 9, 2026

6 Running Back

19 days ago

No priority injuries for this team

HEAD TO HEAD

Arizona

ARI

Indianapolis

IND

NFL

ODDS PICKS PLAYER PROPS FUTURES PLAYER FUTURES INJURIES WEATHER RANKINGS STANDINGS

Spread

Spread
Money
Total
Merged

Game

Game
1H
2H
1Q
2Q
3Q
4Q

This Week

Last Week

Personalize your notifications and get updates on the teams, players or events you care about most. SUN 10/129:30 AM Denver 3-2 31% -7 -105Bet365
N.Y. Jets 0-5 69% +7 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 10/121:00 PM Cleveland 1-4 63% +6 -105Bet365
Pittsburgh 3-1 37% -5½ -120FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 10/121:00 PM Arizona 2-3 54% +9½ -105Bet365
Indianapolis 4-1 46% -9 -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 10/121:00 PM L.A. Rams 3-2 47% -7 -110Caesars
Baltimore 1-4 53% +7 -105Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 10/121:00 PM Seattle 3-2 23% +1 -115Bet365
Jacksonville 4-1 77% +1½ -120FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 10/121:00 PM Dallas 2-2-1 19% -3 -105Bet365
Carolina 2-3 81% +3 -107BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 10/121:00 PM L.A. Chargers 3-2 34% -3½ -105Bet365
Miami 1-4 66% +4 -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 10/121:00 PM New England 3-2 36% -3½ +100Caesars
New Orleans 1-4 64% +3½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 10/124:05 PM Tennessee 1-4 71% +4½ -110Caesars
Las Vegas 1-4 29% -4 -110BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 10/124:25 PM San Francisco 4-1 63% +3½ -115Caesars
Tampa Bay 4-1 37% -3 -117BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 10/124:25 PM Cincinnati 2-3 58% +15 -120BetMGM
Green Bay 2-1-1 42% -14 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 10/128:20 PM Detroit 4-1 64% +2½ -105Bet365
Kansas City 2-3 36% -2 -112BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. MON 10/137:15 PM Buffalo 4-1 12% -4 -105Bet365
Atlanta 2-2 88% +4½ -115FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. MON 10/138:15 PM Chicago 2-2 76% +4½ -110Caesars
Washington 3-2 24% -4½ -102FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTHU 10/098:15 PM Philadelphia 4-2 17 -7½ +100BetMGM
N.Y. Giants 2-4 34 +7½ -105BetMGM

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Arizona Cardinals vs Indianapolis Colts Betting Trends

ATS Records

Arizona

Indianapolis

TEAM MATCHUP

Arizona

Indianapolis

Priority Injuries

Arizona

Indianapolis

Recent Results

Arizona

Indianapolis

HEAD TO HEAD

Arizona

Indianapolis

Arizona

UPCOMING SCHEDULE

Indianapolis