Oct 12, 2025 4:25 PM EDT

Week 6

San Francisco

4-1

Tampa Bay

-3 (-120)o47 (-110)

CBS

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San Francisco 49ers vs Tampa Bay Buccaneers Betting Trends

Updated:Oct 12, 2025 2:14 AM EDT

On October 12, 2025, the San Francisco 49ers will face off against the Tampa Bay Buccaneers at Raymond James Stadium in Tampa, FL. This Sunday night football clash will be broadcast on CBS, promising an electrifying NFL showdown. The 49ers, sporting a strong away record, aim to leverage their offensive prowess against the Buccaneers' defense. Mac Jones is expected to start at quarterback for San Francisco, despite being listed as questionable. The Buccaneers, led by Baker Mayfield, will look to capitalize on their home advantage, although they face challenges with key players like Mike Evans and Chris Godwin Jr. out due to injuries.

Betting trends suggest a close game, with the Buccaneers slightly favored with a -3.5 point spread. San Francisco's potent passing game, averaging 290.6 yards per game, will be a significant factor against Tampa Bay's defense, which allows 218.4 passing yards per game. Meanwhile, Tampa Bay's effective running game, led by Rachaad White, will test the 49ers' defensive line.

The last encounter between these teams on November 10, 2024, saw the 49ers triumph 23-20, a game that went under the total points. For bettors, key insights include the 49ers' strong ATS record as an away team and Tampa Bay's struggles against the spread at home. The total points line is set at 47, with the over/under being a crucial consideration. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

What is the point spread for 49ers vs Buccaneers?

ATS Records

San Francisco

Tampa Bay

All

All
1st half
2nd half
1st quarter
2nd quarter
3rd quarter
4th quarter

3-2 (8th)Against the Spread3-2 (11th)

4-1 (5th)Straight Up4-1 (6th)

+4.7Straight Up Units+3.0

3-2Over / Under3-2

TEAM MATCHUP

San Francisco

Tampa Bay

OFF

DEF

OFF

DEF

21.2Points27

10.4First Half12.6

10.8Second Half14.4

4.6First Quarter3.2

5.8Second Quarter9.4

2.8Third Quarter7.8

7.4Fourth Quarter6.6

375.8Total Yards353.8

5.2Yards Per Play5.7

290.6Passing Yards243.4

26.8 - 40.4 (66.3%)Completions-Attempts22.4 - 34.4 (65.1%)

7Yards Per Passing Play6.7

1.4 (8)Sacks (Yards)1.8 (13)

85.2Rushing Yards110.4

27.8Attempts27.4

3.1Yards Per Rush4

231st Downs20.6

16Passing11.6

5Rushing5.8

2Penalties3.2

6.4 / 14 (45.7%)3rd Down5.4 / 13 (41.5%)

1.2 / 1.6 (75%)4th Down0.6 / 1 (60%)

1.6 / 3.8 (42.1%)Red Zone1.6 / 3.4 (47.1%)

6.4 (53.6)Penalties (Yards)7 (61.2)

0.6Turnovers0.6

-Interceptions0.4

0.6Fumbles Lost0.2

69.6Total Plays63.6

5.2Kickoffs5.6

2.8Returns4.2

64Return Yards99.6

22.9Yards Per Return23.7

3Punts4

2Returns2

16.4Return Yards31.8

8.2Yards Per Return15.9

Priority Injuries

San Francisco

Tampa Bay

PRIORITY

Brock Purdy

Out

Est. Return Oct 19, 2025

13 Quarterback

4 hours ago

PRIORITY

Jauan Jennings

Questionable

Est. Return Oct 12, 2025

15 Wide Receiver

4 hours ago

PRIORITY

Brandon Aiyuk

PUP

Est. Return Oct 12, 2025

11 Wide Receiver

17 days ago

No priority injuries for this team

HEAD TO HEAD

San Francisco

Tampa Bay

NFL

ODDS PICKS PLAYER PROPS FUTURES PLAYER FUTURES INJURIES WEATHER RANKINGS STANDINGS

Spread

Spread
Money
Total
Merged

Game

Game
1H
2H
1Q
2Q
3Q
4Q

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Pittsburgh 3-1 37% -5½ -120FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 10/121:00 PM Arizona 2-3 54% +9½ -105Bet365
Indianapolis 4-1 46% -9 -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 10/121:00 PM L.A. Rams 3-2 47% -7 -110Caesars
Baltimore 1-4 53% +7 -105Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 10/121:00 PM Seattle 3-2 23% +1 -115Bet365
Jacksonville 4-1 77% +1½ -120FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 10/121:00 PM Dallas 2-2-1 19% -3 -105Bet365
Carolina 2-3 81% +3 -107BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 10/121:00 PM L.A. Chargers 3-2 34% -3½ -105Bet365
Miami 1-4 66% +4 -110BetMGM
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New Orleans 1-4 64% +3½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 10/124:05 PM Tennessee 1-4 71% +4½ -110Caesars
Las Vegas 1-4 29% -4 -110BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 10/124:25 PM San Francisco 4-1 63% +3½ -115Caesars
Tampa Bay 4-1 37% -3 -117BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 10/124:25 PM Cincinnati 2-3 58% +15 -120BetMGM
Green Bay 2-1-1 42% -14 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 10/128:20 PM Detroit 4-1 64% +2½ -105Bet365
Kansas City 2-3 36% -2 -112BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. MON 10/137:15 PM Buffalo 4-1 12% -4 -105Bet365
Atlanta 2-2 88% +4½ -115FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. MON 10/138:15 PM Chicago 2-2 76% +4½ -110Caesars
Washington 3-2 24% -4½ -102FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTHU 10/098:15 PM Philadelphia 4-2 17 -7½ +100BetMGM
N.Y. Giants 2-4 34 +7½ -105BetMGM

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San Francisco 49ers vs Tampa Bay Buccaneers Betting Trends

ATS Records

San Francisco

Tampa Bay

TEAM MATCHUP

San Francisco

Tampa Bay

Priority Injuries

San Francisco

Tampa Bay

Recent Results

San Francisco

Tampa Bay

HEAD TO HEAD

San Francisco

Tampa Bay

San Francisco

UPCOMING SCHEDULE

Tampa Bay