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The upcoming clash on September 7, 2025, between the Arizona Cardinals and New Orleans Saints at Caesars Superdome in New Orleans, LA promises to be an electrifying start to the 2025-26 NFL season. The Saints, playing at home, will look to capitalize on their familiarity with the dome environment, while the Cardinals aim to spoil their opener. This NFL showdown is a must-watch, broadcasting live on CBS.
Currently, the odds favor the Arizona Cardinals with a point spread of -6½ -110, while the New Orleans Saints are underdogs at +6½ -110 according to Caesars. The opening odds were slightly different, showing how the market's confidence in the Cardinals has grown. Bettors should consider this shift in odds when placing their bets.
For those interested in totals, the over/under is set at 43.5 with both sides priced at -110. This offers an opportunity for those looking to bet on the scoring dynamics of the game.
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![]() Tennessee 0-272% +4½ -114Caesars | |||||||
Carolina 0-279% +5½ -110Bet365 | |||||||
![]() Washington 1-135% -3 -105Caesars | |||||||
Cleveland 0-278% +8 -110BetMGM | |||||||
Minnesota 1-149% -3 -105BetMGM | |||||||
Philadelphia 2-044% -3 -125Caesars | |||||||
New England 1-159% +2 -110Caesars | |||||||
![]() Tampa Bay 2-018% -6½ -110Caesars | |||||||
Jacksonville 1-159% -1½ -110Caesars | |||||||
![]() L.A. Chargers 2-032% -2½ -118BetRivers | |||||||
Seattle 1-120% -7½ -105Bet365 | |||||||
![]() Chicago 0-281% +1½ -110FanDuel | |||||||
![]() San Francisco 2-051% -2½ -105FanDuel | |||||||
![]() N.Y. Giants 0-278% +6½ -110BetMGM | |||||||
![]() Baltimore 1-128% -4½ -110Caesars | |||||||
Buffalo 3-031 -11 -110Bet365 |
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