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Get ready for an electrifying start to the 2025 NFL season as the Arizona Cardinals face off against the New Orleans Saints on September 7, 2025, at the Caesars Superdome in New Orleans, LA. This matchup promises to set the tone for the season, with both teams eager to showcase their skills. The Cardinals, led by their dynamic quarterback Kyler Murray, are expected to challenge the Saints' seasoned defense, while the Saints will rely on Alvin Kamara's agility to break through the Cardinals' defense.
In terms of game props, look out for the total points market, where the odds suggest a close game. The Saints, known for their robust pass offense, will test the Cardinals' pass defense, while the Cardinals' run offense could exploit any gaps in the Saints' run defense. Our game projections have been spot-on in the last 10 games, with a high hit rate on team totals and touchdowns. Bettors should keep an eye on Alvin Kamara to score the first touchdown, given his favorable odds at Caesars.
For those who want to delve deeper into player stats and prop bets, check out our NFL player props page. Don't miss out on the action and make informed betting decisions with our expert insights. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
 Tennessee 0-273% +4½ -114Caesars | |||||||
 Carolina 0-278% +5½ -110Bet365 | |||||||
 Washington 1-137% -3 -105Caesars | |||||||
 Cleveland 0-279% +8 -110BetMGM | |||||||
 Minnesota 1-151% -3 -105BetMGM | |||||||
 Philadelphia 2-045% -3 -125Caesars | |||||||
 New England 1-161% +2 -110Caesars | |||||||
 Tampa Bay 2-018% -6½ -110Caesars | |||||||
 Jacksonville 1-160% -1½ -105BetMGM | |||||||
 L.A. Chargers 2-030% -2½ -118BetRivers | |||||||
 Seattle 1-119% -7½ -105Bet365 | |||||||
 Chicago 0-282% +1½ -110FanDuel | |||||||
 San Francisco 2-049% -2 -109BetRivers | |||||||
 N.Y. Giants 0-277% +6½ -110BetMGM | |||||||
 Baltimore 1-128% -4½ -110Caesars | |||||||
 Buffalo 3-031 -11 -110Bet365 |
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