Carolina Panthers Vs New England Patriots Picks

Before the anticipated clash between the Carolina Panthers and the New England Patriots on September 28, 2025, fans and bettors alike are buzzing with excitement. This Sunday football showdown will take place at the iconic Gillette Stadium in Foxborough, MA, and promises to be a thrilling matchup in the NFL. With the Panthers coming off a mixed bag of performances, they are eager to prove themselves against the Patriots, who have also had their ups and downs this season.

Our prediction model gives the Carolina Panthers a slight edge, with a predicted score of 22-20 over the New England Patriots. The Panthers are favored with a +5.5 point spread, boasting a 64.1% hit rate, making this an enticing bet for those looking for positive EV. Additionally, the under 43.5 American Total is predicted to hit, given a 53.1% hit rate.

For those tuning in, the game will be broadcasted on FOX, offering a perfect opportunity to follow the action live. Our picks have shown impressive results, especially in the point spread markets, where we've maintained a profitable streak. Explore more of our NFL insights and predictions on the NFL picks page. Ready to take your betting to the next level? Start your OddsTrader Turbo subscription now and gain an edge in your sports betting strategy.