Nov 30, 2025 1:00 PM EST

Week 13

Houston

8-3

Indianapolis

IND

-3½ (-110)o44½ (-110)

CBS

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Houston Texans vs Indianapolis Colts Picks

Updated:Nov 25, 2025 1:45 AM EST

The Houston Texans vs Indianapolis Colts game on November 30, 2025, promises to be a thrilling NFL Sunday football matchup at Lucas Oil Stadium in Indianapolis, IN. This game is part of the 2025-26 NFL regular season Week 13 and will be broadcast on CBS, making it accessible for fans and bettors nationwide.

Our picks and predictions favor the Indianapolis Colts to win this game with a predicted score of 24-20. The Colts are expected to cover the spread of -4 with a 50.5% hit rate and an EV of -3.4%, while the Texans have a 49.5% hit rate on the spread with a slight negative EV. The predicted total score is around 44, slightly under the 46.5 line, which has a 50.7% hit rate and a modest negative EV, indicating a lean towards the under bet.

Our prediction model has been profitable in the last 10 games, especially with the Under 46.5 market, which boasts a hit rate of 50.7% and an EV of -1.7%, making it a smart betting tip for this matchup. The Colts have shown strong performance recently, winning 6 of their last 10 games against the spread, which adds confidence to our picks.

For bettors looking to make informed decisions, these stats and insights provide a valuable edge. Check out more NFL picks and predictions on our dedicated NFL picks page to stay ahead of the game. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

What is the predicted score for the game?

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ODDS PICKS PLAYER PROPS FUTURES PLAYER FUTURES INJURIES WEATHER RANKINGS STANDINGS

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Personalize your notifications and get updates on the teams, players or events you care about most. THU 11/271:00 PM Green Bay 7-3-1 61% +3 -115Bet365
Detroit 7-4 39% -2½ -114Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. THU 11/274:30 PM Kansas City 6-5 52% -3 -114Caesars
Dallas 5-5-1 48% +3½ -118BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. THU 11/278:20 PM Cincinnati 3-8 84% +7 -110BetMGM
Baltimore 6-5 16% -6½ -115Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. FRI 11/283:00 PM Chicago 8-3 60% +7 -114Caesars
Philadelphia 8-3 40% -6½ -125BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/301:00 PM Houston 6-5 66% +4½ -110BetMGM
Indianapolis 8-3 34% -3½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/301:00 PM Arizona 3-8 55% +3 -109Caesars
Tampa Bay 6-5 45% -2½ -115Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/301:00 PM Jacksonville 7-4 13% -6½ -110Bet365
Tennessee 1-10 87% +6½ -105BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/301:00 PM L.A. Rams 9-2 - -10 -110Bet365
Carolina 6-6 - +10½ -109BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/301:00 PM New Orleans 2-9 88% +6 -110BetMGM
Miami 4-7 12% -5½ -112BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/301:00 PM Atlanta 4-7 20% -2½ -110Bet365
N.Y. Jets 2-9 80% +2½ -105BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/301:00 PM San Francisco 8-4 60% -6 -109Caesars
Cleveland 3-8 40% +6½ -122FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/304:05 PM Minnesota 4-7 78% +10½ -112BetRivers
Seattle 8-3 22% -10½ -105Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/304:25 PM Buffalo 7-4 19% -3½ -115Caesars
Pittsburgh 6-5 81% +4½ -115BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/304:25 PM Las Vegas 2-9 80% +9½ -105BetMGM
L.A. Chargers 7-4 20% -9½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/308:20 PM Denver 9-2 13% -6½ -110Bet365
Washington 3-8 87% +6½ -102BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. MON 12/018:15 PM N.Y. Giants 2-10 80% +7½ -115Caesars
New England 10-2 20% -7½ -105Caesars

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