- Spread
- Money
- Total
- Merged
Personalize your notifications and get updates on the teams, players or events you care about most.
Dec 22, 2025 8:15 PM EST
Week 16
SF
-6 (-110)o46½ (-110)
ESPN, 206MATCHUP
PREDICTION
ODDS
PLAYER PROPS
GAME PROPS
INJURIES
WEATHER
CHAT
Event NotificationsStay on top of the action with alerts for game start, scoring, odds updates, predictions and more.
Don't show me this again
San Francisco 49ers vs Indianapolis Colts Injury Report
Updated:Dec 18, 2025 1:52 AM EST
The upcoming Monday night football game on December 22, 2025, features a highly anticipated NFL regular season Week 16 matchup between the San Francisco 49ers and the Indianapolis Colts. This exciting event will take place at Lucas Oil Stadium in Indianapolis, IN, and will be broadcast live on ESPN. Bettors will want to keep a close eye on the injury report as it plays a crucial role in shaping betting strategies and outcomes.
Currently, there are no reported injuries for either team, which means both the San Francisco 49ers and the Indianapolis Colts will likely be fielding their strongest lineups. This clean injury report can significantly impact player performance predictions and game dynamics, making it an essential factor for bettors to consider. Understanding player statuses and injury lists can help bettors make smarter wagers and capitalize on potential advantages.
For comprehensive details on player injuries and statuses, bettors can visit the NFL injury list page to stay updated on any last-minute changes. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
OFFENSE DEPTH CHART
QUARTERBACK
Player Name
CP/ATT
YDS
TD
INT
Brock
Purdy
Purdy
129/190
1442
12
7
13 Quarterback
Mac
Jones
Jones
201/289
2151
13
6
10 Quarterback
WIDE RECEIVER
Player Name
REC
YDS
TD
AVG
Demarcus
Robinson
Robinson
15-27
199
0
13.3
5 Wide Receiver
Jauan
Jennings
Jennings
44-74
495
7
11.3
15 Wide Receiver
Ricky
Pearsall
Pearsall
31-45
443
0
14.3
1 Wide Receiver
Jordan
Watkins
Watkins
2-3
26
0
13.0
17 Wide Receiver
Skyy
Moore
Moore
4-6
64
0
16.0
9 Wide Receiver
Kendrick
Bourne
Bourne
33-46
499
0
15.1
84 Wide Receiver
LEFT TACKLE
Player Name
GS
G
P
PY
Trent
Williams
Williams
14
14
4
35
71 Offensive Tackle
CENTER
Player Name
GS
G
P
PY
Jake
Brendel
Brendel
12
12
3
26
64 Offensive Line
Matt
Hennessy
Hennessy
2
14
0
0
61 Offensive Line
RIGHT TACKLE
Player Name
GS
G
P
PY
Colton
McKivitz
McKivitz
14
14
5
30
68 Offensive Line
Austen
Pleasants
Pleasants
0
12
0
0
62 Offensive Line
RUNNING BACK
Player Name
CAR
YDS
TD
AVG
Christian
McCaffrey
McCaffrey
259
922
9
3.6
23 Running Back
Kyle
Juszczyk
Juszczyk
2
-3
0
-1.5
44 Fullback
Brian
Robinson Jr.
Robinson Jr.
81
349
2
4.3
3 Running Back
Isaac
Guerendo
Guerendo
No information available
31 Running Back
Jordan
James
James
No information available
29 Running Back
TIGHT END
Player Name
REC
YDS
TD
AVG
George
Kittle
Kittle
45-54
484
6
10.8
85 Tight End
Luke
Farrell
Farrell
11-14
85
2
7.7
89 Tight End
Jake
Tonges
Tonges
26-35
226
4
8.7
88 Tight End
LEFT GUARD
Player Name
GS
G
P
PY
Spencer
Burford
Burford
6
8
1
5
74 Offensive Line
RIGHT GUARD
Player Name
GS
G
P
PY
Dominick
Puni
Puni
14
14
3
20
77 Offensive Line
Connor
Colby
Colby
6
10
3
20
75 Offensive Line
DEFENSE DEPTH CHART
LEFT END
Player Name
T-A
SACK
TFL
TD
Bryce
Huff
Huff
13-12
4
6
0
47 Defensive Line
Robert
Beal Jr.
Beal Jr.
1-8
0
0
0
51 Defensive Line
DEFENSIVE TACKLE
Player Name
T-A
SACK
TFL
TD
Jordan
Elliott
Elliott
7-22
0
1
0
92 Defensive Line
Kalia
Davis
Davis
8-14
0.5
3
0
93 Defensive Line
Alfred
Collins
Collins
2-8
0
0
0
95 Defensive Tackle
C.J.
West
West
9-7
0
1
0
99 Defensive Tackle
Kevin
Givens
Givens
1-1
0
0
0
90 Defensive Line
LEFT CORNERBACK
Player Name
INT
YDS
PD
TD
Renardo
Green
Green
0
0
9
0
0 Cornerback
Darrell
Luter Jr.
Luter Jr.
No information available
28 Cornerback
SAFETY
Player Name
INT
YDS
PD
TD
Ji'Ayir
Brown
Brown
2
4
5
0
27 Safety
Malik
Mustapha
Mustapha
1
0
2
0
6 Safety
Jason
Pinnock
Pinnock
No information available
25 Safety
Marques
Sigle
Sigle
0
0
2
0
36 Safety
RIGHT END
Player Name
T-A
SACK
TFL
TD
Sam
Okuayinonu
Okuayinonu
17-14
2
3
0
91 Defensive Line
Keion
White
White
3-4
1.5
1
0
56 Defensive Line
Clelin
Ferrell
Ferrell
11-9
4
4
0
96 Defensive Line
LINEBACKER
Player Name
T-A
SACK
TFL
TD
Dee
Winters
Winters
58-31
0
7
0
53 Linebacker
Upton
Stout
Stout
33-33
1
4
0
20 Cornerback
Tatum
Bethune
Bethune
23-41
0
2
0
48 Linebacker
Luke
Gifford
Gifford
3-9
0
0
0
57 Linebacker
Chase
Lucas
Lucas
1-1
0
0
0
26 Cornerback
Curtis
Robinson
Robinson
16-18
0
1
0
59 Linebacker
Nick
Martin
Martin
4-2
0
0
0
45 Linebacker
Garret
Wallow
Wallow
No information available
49 Linebacker
RIGHT CORNERBACK
Player Name
INT
YDS
PD
TD
Deommodore
Lenoir
Lenoir
2
90
5
0
2 Defensive Back
Siran
Neal
Neal
No information available
33 Cornerback
SPECIAL TEAMS DEPTH CHART
KICKER
Player Name
FG
LONG
XP
PTS
Eddy
Pineiro
Pineiro
25
59
22
97
18 Kicker
PUNTER
Player Name
PUNTS
AVG
I20
LONG
Thomas
Morstead
Morstead
38
43.6
19
55
7 P
HOLDER
Player Name
Thomas
Morstead
Morstead
7 P
KICK RETURNER
Player Name
RET
AVG
TD
LONG
Brian
Robinson Jr.
Robinson Jr.
9
31.9
0
46
3 Running Back
Skyy
Moore
Moore
25
28.1
0
98
9 Wide Receiver
Isaac
Guerendo
Guerendo
5
20.0
0
25
31 Running Back
PUNT RETURNER
Player Name
RET
AVG
TD
LONG
Skyy
Moore
Moore
22
12.4
0
66
9 Wide Receiver
Jordan
Watkins
Watkins
No information available
17 Wide Receiver
Ricky
Pearsall
Pearsall
No information available
1 Wide Receiver
LONG SNAPPER
Player Name
Jon
Weeks
Weeks
46 Long Snapper
Powered by:
NFL
Spread
Game
- Game
- 1H
- 2H
- 1Q
- 2Q
- 3Q
- 4Q
This Week
Last Week
NFLWeek 16
 Seattle 11-355% -1½ -108FanDuel | |||||||
 Washington 4-1085% +6½ -110Caesars | |||||||
 Chicago 10-446% +1½ -120FanDuel | |||||||
 Cleveland 3-1143% +10½ -114Caesars | |||||||
 New Orleans 4-1088% -4½ -110Bet365 | |||||||
 N.Y. Giants 2-1249% +3 -113Caesars | |||||||
 Carolina 7-787% +3 -110Bet365 | |||||||
 Tennessee 2-1286% +3 -105Bet365 | |||||||
 Dallas 6-7-142% -2 -110Bet365 | |||||||
 Miami 6-866% +4½ -110BetRivers | |||||||
 Arizona 3-1127% +3 -113Caesars | |||||||
 Denver 12-257% -3 -110Bet365 | |||||||
 Detroit 8-66% -6½ -120FanDuel | |||||||
 Houston 9-542% -14 -108BetRivers | |||||||
 Baltimore 7-769% -2½ -121SugarHouse | |||||||
 Indianapolis 8-684% +6½ -110BetMGM |
Download the app© OddsTrader 2025 All Rights Reserved
The content on this site is for entertainment purposes only. OddsTrader makes no representation or warranty as to the accuracy of the information given or the outcome of any game or event. Please be aware of and respect the laws regarding sports betting for your jurisdiction as they vary from state to state. OddsTrader does not target underaged persons. Using this information to contravene any law or statute is prohibited. This site contains commercial content, and OddsTrader may be compensated for the links provided on this site.Disclosure.
OddsTrader is licensed to operate in NJ, NY, PA, IN, CO, IA, IL, VA, WV, TN, CT, MI, AZ, LA, WY, OR, KS, DC, MA & OH.
Seek help with a gambling addiction at 1-800-Gambler.
OddsTrader uses cookies to help us provide, protect & improve our services. See ourPrivacy Policyfor more details.
ACCEPT & CLOSE