Dec 22, 2025 8:15 PM EST

Week 16

San Francisco

8-6

Indianapolis

-6 (-112)o46½ (-110)

ESPN, 206

MATCHUP PREDICTION ODDS PLAYER PROPS GAME PROPS INJURIES WEATHER

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San Francisco 49ers vs Indianapolis Colts Game Props

Updated:Dec 18, 2025 1:16 AM EST

The upcoming Monday night football clash on December 22, 2025, between the San Francisco 49ers and the Indianapolis Colts at Lucas Oil Stadium in Indianapolis, IN, promises an exciting NFL showdown. This game features a compelling matchup of pass offense versus pass defense and run offense versus run defense, which will heavily influence the betting landscape and game props.

San Francisco's pass offense will challenge Indianapolis' pass defense, while the Colts' run offense looks to exploit the 49ers' run defense. Additionally, the Colts' pass protection will be tested against the 49ers' aggressive pass rush, adding to the strategic depth of this game. These dynamics create excellent opportunities for bettors focusing on prop bets and team props related to touchdowns and field goals.

Our game projections highlight the "Player to score first touchdown" market as a high EV prop bet with a strong hit rate over the past 10 games. Jonathan Taylor stands out as a favorite with a favorable EV and solid hit rate, making him a prime candidate for bettors looking to capitalize on this market. The 49ers and Colts have shown consistent performance in these areas, and our projections have maintained profitability, giving bettors an edge.

This NFL game will be broadcast on ESPN, offering fans and bettors a prime viewing experience. For those looking to dive deeper into player performance and optimize their bets, consider exploring our detailed player props and NFL picks. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

How reliable are the prop bet projections?

Total Points Odds/Even

BEST LINE

ODDTotal Points Odds/Even

EVENTotal Points Odds/Even

Total Points Odds/Even (1st Half)

BEST LINE

ODDTotal Points Odds/Even

EVENTotal Points Odds/Even

Both Teams To Score 10+ Points

BEST LINE

YESBoth Teams To Score 10+ Points

NOBoth Teams To Score 10+ Points

Both Teams To Score 20+ Points

BEST LINE

YESBoth Teams To Score 20+ Points

NOBoth Teams To Score 20+ Points

Both Teams To Score 30+ Points

BEST LINE

YESBoth Teams To Score 30+ Points

NOBoth Teams To Score 30+ Points

Will there be a Safety

BEST LINE

YESWill there be a Safety

NOWill there be a Safety

Indianapolis Team Total

BEST LINE

OVERIndianapolis Team Total

UNDERIndianapolis Team Total

San Francisco Team Total

BEST LINE

OVERSan Francisco Team Total

UNDERSan Francisco Team Total

Indianapolis Total (First Half)

BEST LINE

OVERIndianapolis Total

UNDERIndianapolis Total

San Francisco Total (First Half)

BEST LINE

OVERSan Francisco Total

UNDERSan Francisco Total

Indianapolis Total Touchdown

BEST LINE

OVERIndianapolis Total Touchdown

UNDERIndianapolis Total Touchdown

San Francisco Total Touchdown

BEST LINE

OVERSan Francisco Total Touchdown

UNDERSan Francisco Total Touchdown

Will there be Overtime

EXPECTED VALUECOVER PROB.EXPECTED VALUEBEST LINE

YESWill there be Overtime

+4.6%

NOWill there be Overtime

-7.9%

First Team to 10 Points

BEST LINE

San FranciscoFirst Team to 10 Points

IndianapolisFirst Team to 10 Points

NEITHERFirst Team to 10 Points

First Team to 15 Points

BEST LINE

San FranciscoFirst Team to 15 Points

IndianapolisFirst Team to 15 Points

NEITHERFirst Team to 15 Points

First Team to 20 Points

BEST LINE

San FranciscoFirst Team to 20 Points

IndianapolisFirst Team to 20 Points

NEITHERFirst Team to 20 Points

First Team to 25 Points

BEST LINE

San FranciscoFirst Team to 25 Points

IndianapolisFirst Team to 25 Points

NEITHERFirst Team to 25 Points

First Team to 30 Points

BEST LINE

San FranciscoFirst Team to 30 Points

IndianapolisFirst Team to 30 Points

NEITHERFirst Team to 30 Points

First Team to 35 Points

BEST LINE

San FranciscoFirst Team to 35 Points

IndianapolisFirst Team to 35 Points

NEITHERFirst Team to 35 Points

Team to score first field goal

EXPECTED VALUECOVER PROB.EXPECTED VALUEBEST LINE

San FranciscoTeam to score first field goal

-14.2%

IndianapolisTeam to score first field goal

+7.6%

Team to score most touchdowns

BEST LINE

San FranciscoTeam to score most touchdowns

IndianapolisTeam to score most touchdowns

Team to score the first touchdown

EXPECTED VALUECOVER PROB.EXPECTED VALUEBEST LINE

San FranciscoTeam to score the first touchdown

-33.3%

IndianapolisTeam to score the first touchdown

+28.7%

Team to score last

BEST LINE

San FranciscoTeam to score last

IndianapolisTeam to score last

Team to score first

BEST LINE

San FranciscoTeam to score first

IndianapolisTeam to score first

Team to use first challenge

BEST LINE

San FranciscoTeam to use first challenge

IndianapolisTeam to use first challenge

Touchdowns

BEST LINE

OVERTouchdowns

UNDERTouchdowns

NFL

ODDS PICKS PLAYER PROPS FUTURES PLAYER FUTURES INJURIES WEATHER RANKINGS STANDINGS

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Personalize your notifications and get updates on the teams, players or events you care about most. THU 12/188:15 PM L.A. Rams 11-3 45% +2 -114BetRivers
Seattle 11-3 55% -1½ -108FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 12/205:00 PM Philadelphia 9-5 15% -6½ -109Caesars
Washington 4-10 85% +6½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 12/208:20 PM Green Bay 9-4-1 54% +1½ -134Caesars
Chicago 10-4 46% +1½ -120FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/211:00 PM Buffalo 10-4 57% -10 -115Bet365
Cleveland 3-11 43% +10½ -114Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/211:00 PM N.Y. Jets 3-11 12% +4½ -107Caesars
New Orleans 4-10 88% -4½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/211:00 PM Minnesota 6-8 51% -2½ -122FanDuel
N.Y. Giants 2-12 49% +3 -113Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/211:00 PM Tampa Bay 7-7 13% -3 -105BetMGM
Carolina 7-7 87% +3 -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/211:00 PM Kansas City 6-8 14% -3 -110Caesars
Tennessee 2-12 86% +3 -105Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/211:00 PM L.A. Chargers 10-4 58% +2½ -110Caesars
Dallas 6-7-1 42% -2 -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/211:00 PM Cincinnati 4-10 34% -4 -110Bet365
Miami 6-8 66% +4½ -110BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/214:05 PM Atlanta 5-9 73% -2½ -115FanDuel
Arizona 3-11 27% +3 -113Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/214:05 PM Jacksonville 10-4 43% +3 -105FanDuel
Denver 12-2 57% -3 -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/214:25 PM Pittsburgh 8-6 94% +7 -109Caesars
Detroit 8-6 6% -6½ -120FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/214:25 PM Las Vegas 2-12 58% +14½ -115BetMGM
Houston 9-5 42% -14 -108BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/218:20 PM New England 11-3 31% +3 -113Caesars
Baltimore 7-7 69% -2½ -121SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. MON 12/228:15 PM San Francisco 10-4 16% -6 -110Bet365
Indianapolis 8-6 84% +6½ -110BetMGM

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