San Francisco 49ers vs Indianapolis Colts Player Props

The upcoming Monday night football clash on December 22, 2025, between the San Francisco 49ers and Indianapolis Colts at Lucas Oil Stadium in Indianapolis, IN, is a must-watch NFL event. This game offers prime opportunities for bettors focusing on player props, with detailed player projections highlighting key matchups. The Colts' pass offense will be challenged by the 49ers' pass defense, making passing yards and attempts a critical prop bet market. Meanwhile, the 49ers' run offense versus the Colts' run defense will influence rushing yards bets, especially given the Colts' retractable dome conditions that may affect gameplay pace.

Our recent prop bet results show a strong hit rate and positive EV, particularly in passing yards and player longest reception markets, making these the best bets for this game. For example, the Colts' Philip Rivers passing yards prop holds a 53.4% hit rate and a slight positive EV, suggesting solid betting value. Bettors can leverage these insights to make smarter wagers on player props and prop bets, supported by our comprehensive player projections. This game will be broadcast on ESPN, providing live coverage to enhance the viewing and betting experience.

For those looking to dive deeper, check out the latest NFL player props for more detailed insights. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.