Player Props San Francisco 49ers vs Indianapolis Colts

The Monday night football clash on December 22, 2025, between the San Francisco 49ers and Indianapolis Colts at Lucas Oil Stadium in Indianapolis, IN, is a must-watch NFL event. This game offers an exciting opportunity for bettors with a variety of player props to consider. The Colts' offense will look to challenge the 49ers' defense, particularly in passing and rushing yards, making player projections crucial for smart betting decisions.

Indianapolis boasts strong passing options with Alec Pierce and Michael Pittman Jr. showing promising receiving yards projections, while Jonathan Taylor's rushing yards present a solid prop bet with a hit rate over 58% and positive EV. On the other side, San Francisco's Christian McCaffrey stands out with a high expected value on his total rushing and receiving yards, making his player props highly attractive. The 49ers' Brock Purdy's passing attempts and yards also provide insightful prop bets given his under projections.

The Colts' pass offense versus the 49ers' pass defense and the 49ers' run offense against the Colts' run defense create a dynamic matchup that will influence prop bets. The pace of play expected on Monday night football favors a balanced attack, enhancing opportunities in player props markets. Our prop bet results from the last 10 games show profitable trends in receiving yards and total rushing plus receiving yards markets, supporting confidence in these projections.

Catch this exciting NFL showdown on ESPN and explore more detailed player props on the NFL player props page. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.