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The Los Angeles Chargers are set to face off against the San Francisco 49ers on August 23, 2025, at Levi's Stadium in Santa Clara, CA. This Saturday football clash is a critical preseason matchup, with both teams looking to fine-tune their strategies. The Chargers, led by quarterback Justin Herbert, will aim to leverage their strong passing offense against the 49ers' solid pass defense. Meanwhile, the 49ers, with Brock Purdy at the helm, will focus on exploiting the Chargers' run defense.
In their last encounter on August 25, 2023, the Chargers triumphed over the 49ers with a score of 23-12. This game is crucial for both teams as they prepare for the regular season. The Chargers' recent performance against the Rams, despite a narrow 22-23 loss, showcased their offensive capabilities. On the other hand, the 49ers' victory over the Raiders, 22-19, highlighted their defensive prowess.
The betting odds favor the Chargers with a -2 point spread, and the total points are set at 35.5. Bettors should consider the Chargers' recent form and the 49ers' injury list, which includes key players like Brandon Aiyuk on the PUP list. For those looking to make informed bets, the Chargers' passing game might offer an edge. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
Catch all the action live on NFL Network and make sure to check out the last matchup between these two teams!
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 Buffalo 2-025% -11 -125BetMGM | |||||||
 Tennessee 0-271% +4½ -118FanDuel | |||||||
 Carolina 0-284% +6 -114BetRivers | |||||||
 Washington 1-127% -3½ +100Caesars | |||||||
 Cleveland 0-275% +8 -110BetMGM | |||||||
 Minnesota 1-145% -2½ -130BetMGM | |||||||
 Philadelphia 2-039% -3 -125Caesars | |||||||
 New England 1-162% +1½ -105Caesars | |||||||
 Tampa Bay 2-019% -6½ -113BetRivers | |||||||
 Jacksonville 1-160% -1 -115Bet365 | |||||||
 L.A. Chargers 2-030% -2½ -112BetRivers | |||||||
 Seattle 1-125% -7½ -105Bet365 | |||||||
 Chicago 0-280% +1½ -118FanDuel | |||||||
 San Francisco 2-051% -2½ -110BetRivers | |||||||
 N.Y. Giants 0-280% +6½ -110BetMGM | |||||||
 Baltimore 1-128% -4½ -110Caesars |
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