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The upcoming NFL preseason clash between the Los Angeles Chargers and San Francisco 49ers on August 23, 2025, at Levi's Stadium in Santa Clara, CA, promises a thrilling matchup for football fans and bettors alike. Both teams are eager to showcase their talents in this early season test. The Chargers, known for their dynamic offense, face a formidable opponent in the 49ers, who boast a solid defense. This game will be broadcasted on NFL+, providing fans with a front-row seat to all the action.
Our picks for this game suggest a close contest, with the Chargers having a slight edge based on recent performances. The predicted score is 24-21 in favor of the Chargers, making them a valuable bet on the moneyline. Historically, our predictions have a high hit rate, particularly in games involving the 49ers, with profitable outcomes in the last 10 matchups. This trend makes a compelling case for bettors considering their next move.
For those looking to enhance their betting strategy, our prediction model has been particularly successful with the Chargers in 2-way markets, boasting a 72% coverage percentage in recent matchups. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge. For more insights and betting tips, check out our NFL picks page and make an informed decision.
Arizona 2-176% PK -110Caesars | |||||||
![]() Pittsburgh 2-155% +3 -120SugarHouse | |||||||
![]() Tampa Bay 3-070% +3½ -110Caesars | |||||||
Buffalo 3-013% -16 -118BetMGM | |||||||
New England 1-267% -5½ -110Caesars | |||||||
![]() Atlanta 1-278% +2½ -106SugarHouse | |||||||
Detroit 2-10% -8½ -105Caesars | |||||||
![]() Houston 0-329% -7 -110Caesars | |||||||
![]() N.Y. Giants 0-390% +6½ -118FanDuel | |||||||
![]() San Francisco 3-025% -3 -120Caesars | |||||||
![]() L.A. Rams 2-142% -3½ -110Caesars | |||||||
![]() Las Vegas 1-287% PK -110Caesars | |||||||
![]() Kansas City 1-2- +2½ -102FanDuel | |||||||
Dallas 1-278% +7 -115Caesars | |||||||
Miami 0-332% -2½ -118BetMGM | |||||||
Denver 1-214% -7 -110Bet365 |
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