49ers vs Rams: Betting Trends & Predictions

The highly anticipated Thursday night football clash between the Los Angeles Rams and the San Francisco 49ers on October 2, 2025, at SoFi Stadium in Inglewood, CA, promises an exhilarating showdown. The Rams, with a strong 3-1-0 ATS record, are set to leverage their home advantage, having been undefeated at home this season. Matthew Stafford, the Rams' starting quarterback, has consistently demonstrated his prowess with a passing yard average of 267.5, complemented by their robust pass offense. On the other hand, the 49ers, led by Brock Purdy, who is questionable for the game but expected to play, have a commendable away record, offering a fierce competition. Their pass defense, allowing only 165 passing yards per game, poses a significant challenge for the Rams. The game insights suggest a tight contest, with the Rams favored by 5.5 points. Given the current lineup and injury reports, the Rams' offensive line will need to counter the 49ers' formidable defensive strategies. The total points line is set at 47, indicating expectations of a high-scoring affair. Fans can catch the action live on Amazon Prime Video. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge. Don't forget to check out the last matchup on December 12, 2024, which the Rams won 12-6.