San Francisco 49ers vs Philadelphia Eagles Picks

The upcoming NFL clash on January 11, 2026, between the San Francisco 49ers and Philadelphia Eagles at Lincoln Financial Field in Philadelphia, PA, promises an exciting start to the 2025-26 season. This Sunday football game will be broadcast on Fox, offering fans and bettors a thrilling experience.

Our picks for this game favor the Philadelphia Eagles, with a predicted score of 24 to 23 against the San Francisco 49ers. The spread prediction leans towards Philadelphia -4.5, and the total points are expected to go over 44.5, with a predicted total score of approximately 47.33. These betting tips come backed by a solid prediction model that has shown a strong hit rate, especially in point spreads and American totals, winning over 50% of recent games. This model's high EV in the American Total market makes it particularly valuable for bettors looking to make smart wagers.

For bettors looking to place informed bets, our detailed analysis and picks for the San Francisco 49ers vs Philadelphia Eagles game can provide a profitable edge. Check out our comprehensive NFL picks and predictions to stay ahead of the curve. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.