Seattle Seahawks vs San Francisco 49ers Injury Report

The upcoming NFL regular season Week 18 game on January 3, 2026, between the Seattle Seahawks and San Francisco 49ers at Levi's Stadium in Santa Clara, CA, is drawing significant attention. This Saturday football matchup will be broadcast on ABC and ESPN, making it a must-watch event for football fans and sports bettors alike. In terms of player injuries, the 49ers have several key players with varying injury statuses. Offensive Tackle Trent Williams is fully participating in practice but remains questionable for the game due to a knee issue. Running Back Christian McCaffrey, also questionable with a calf injury, is expected to play. Tight End George Kittle is questionable as he is being activated from injured reserve with a hamstring issue. Defensive Line players Yetur Gross-Matos and Sam Okuayinonu are questionable with knee and ankle concerns, respectively. Wide Receiver Ricky Pearsall is also questionable due to a knee injury. Cornerback Renardo Green is out with a toe injury, and Linebacker Tatum Bethune is not practicing due to an ankle injury. Quarterback Kurtis Rourke is out with a knee injury but practiced fully recently. Seattle Seahawks' injury report shows Nose Tackle Jarran Reed is fully participating in practice despite wrist and thumb concerns. Wide Receiver Cody White is inactive due to an abdomen injury. Tackle Charles Cross is out with a finger injury but has participated in team drills. Abraham Lucas is fully practicing after an abdominal injury. Free Safety Coby Bryant is out with a foot injury, while Tight End AJ Barner is limited in practice with elbow, knee, and shoulder issues. Fullback Robbie Ouzts is questionable with elbow and personal issues. Understanding these player injuries is crucial for bettors aiming to make smart wagers. Injuries to core players like McCaffrey and Kittle could impact the 49ers' offensive capabilities, while key absences on the Seahawks' defense might influence the game's outcome. Bettors can use this injury report to assess team strengths and weaknesses before placing bets. For more detailed injury updates, check out the NFL injury updates. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.