Jan 3, 2026 8:00 PM EST

Week 18

Seattle

12-4

San Francisco

SEA

-1½ (-110)o49 (-110)

ABC/ESPN

MATCHUP PREDICTION ODDS PLAYER PROPS GAME PROPS INJURIES WEATHER

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Seattle Seahawks vs San Francisco 49ers Picks

Updated:Dec 31, 2025 1:39 AM EST

The upcoming NFL Week 18 showdown on January 4, 2026, features the Seattle Seahawks visiting the San Francisco 49ers at Levi's Stadium in Santa Clara, CA. This Saturday football game is set to broadcast on ABC and ESPN, offering fans and bettors alike a prime viewing experience. The Seattle Seahawks come into this matchup with strong momentum, and our picks reflect a confident stance on their performance.

Our prediction model forecasts a close game with the Seattle Seahawks edging out the San Francisco 49ers 26-23. The best bet lies with Seattle on the moneyline at -1 spread, supported by a 54.2% hit rate and a positive expected value (EV) of 1.1%. The total points are expected to stay under 49.5, aligning with our American Total market insights showing a 51.1% cover percentage and near-neutral EV. This data-driven approach highlights the value in betting on Seattle and the under total, helping you make smarter betting decisions.

Over the last 10 games, our NFL predictions have been profitable, boasting a 59.3% hit rate on the 2-way market for Seattle, and a strong performance in point spread bets. These stats underline the reliability of our picks and betting tips for this NFL clash. For more detailed insights and expert analysis, check out our comprehensive NFL picks page and consider starting your OddsTrader Turbo subscription to gain an edge in your betting strategy. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

What is the best bet for the Seattle Seahawks vs San Francisco 49ers game?

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ODDS PICKS PLAYER PROPS FUTURES PLAYER FUTURES INJURIES WEATHER RANKINGS STANDINGS

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Personalize your notifications and get updates on the teams, players or events you care about most. SAT 01/034:30 PM Carolina 8-8 58% +3 -120FanDuel
Tampa Bay 7-9 42% -2½ -115Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 01/038:00 PM Seattle 13-3 60% -1 -113BetRivers
San Francisco 12-4 40% +1½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 01/041:00 PM Green Bay 9-6-1 44% +6½ -110Caesars
Minnesota 8-8 56% -5½ -120FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 01/041:00 PM Indianapolis 8-8 63% +10½ -112Caesars
Houston 11-5 37% -10 -112BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 01/041:00 PM Cleveland 4-12 73% +7½ -110Caesars
Cincinnati 6-10 27% -7½ -109Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 01/041:00 PM Dallas 7-8-1 22% -3½ -108Caesars
N.Y. Giants 3-13 78% +3½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 01/041:00 PM New Orleans 6-10 45% +3½ -112BetRivers
Atlanta 7-9 55% -3 -114Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 01/041:00 PM Tennessee 3-13 67% +12½ -110Bet365
Jacksonville 12-4 33% -12 -115SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 01/044:25 PM Miami 7-9 91% +10½ -109Caesars
New England 13-3 9% -10½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 01/044:25 PM Kansas City 6-10 67% -5½ -110Caesars
Las Vegas 2-14 33% +6 -117SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 01/044:25 PM Detroit 8-8 67% +3 -114Caesars
Chicago 11-5 33% -2½ -117BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 01/044:25 PM N.Y. Jets 3-13 96% +7½ -112BetRivers
Buffalo 11-5 4% -7 -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 01/044:25 PM Washington 4-12 90% +7 -107Caesars
Philadelphia 11-5 10% -7 -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 01/044:25 PM Arizona 3-13 73% +7½ -115Caesars
L.A. Rams 11-5 27% -7 -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 01/044:25 PM L.A. Chargers 11-5 72% +12½ -110Bet365
Denver 13-3 28% -11½ -110FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 01/048:20 PM Baltimore 8-8 21% -3½ -105Bet365
Pittsburgh 9-7 79% +3½ -113Caesars

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