Betting Trends Tennessee Titans vs San Francisco 49ers

The upcoming NFL clash on December 14, 2025, between the Tennessee Titans and the San Francisco 49ers at Levi's Stadium in Santa Clara, CA, promises to be a thrilling Sunday football matchup. The 49ers, holding a strong home record of 3-2 and an ATS record of 8-5-0, will leverage their offensive prowess led by quarterback Brock Purdy. Despite Christian McCaffrey being questionable, his potential participation boosts the 49ers' running game. The Titans, with a 2-4 away record and an ATS of 6-7-0, face challenges but bring their own strengths with quarterback Cam Ward, who is expected to start. The 49ers boast a superior pass offense averaging 242.6 yards to the Titans' 161.3, while the Titans have a slight edge in rushing yards at 84.9 compared to the 49ers' 98.5.

Defensively, the 49ers excel with a robust pass defense allowing just 232 passing yards on average, whereas the Titans concede 228.5. The 49ers' pass protection is solid against the Titans' aggressive pass rush, which could be a deciding factor. The point spread currently favors the 49ers by 12.5 points with a total points line set at 44.5, indicating expectations of a moderately high-scoring game. Betting trends suggest the 49ers' home advantage and offensive efficiency make them the best bet, especially with the Titans' inconsistent away performance. The game will be broadcast on FOX, providing ample viewing opportunity.

Recent performances show the 49ers have been strong, winning 4 of their last 5 games, while the Titans have struggled with only 1 win in their last 5. In their last matchup on August 10, 2024, the Titans edged out a 17-13 win, adding intrigue to this December rematch. Utilize these betting insights and stats to make an informed wager. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.