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The Tennessee Titans vs San Francisco 49ers injury report for the NFL Week 15 matchup on December 14, 2025, at Levi's Stadium in Santa Clara, CA, is crucial for bettors looking to make informed wagers. This Sunday football game, broadcast on FOX, features significant player injuries that could impact the outcome.
The Titans face several key absences with Calvin Ridley (WR) on injured reserve due to a fibula surgery, expected to return February 9, 2026. Defensive tackle Shy Tuttle is questionable with a concussion but participated fully in practice. Offensive lineman Blake Hance and cornerback L'Jarius Sneed are on injured reserve, sidelined with shoulder and quadriceps injuries respectively. Quarterback Will Levis is also on IR following shoulder surgery, unavailable until February 2026. Other notable Titans injuries include linebacker Anfernee Orji (knee ACL), outside linebacker Ali Gaye (knee), and wide receiver Bryce Oliver (knee), all on injured reserve with expected returns after this game. These absences weaken the Titans' defense and offense, potentially affecting their game plan.
For the San Francisco 49ers, several starters are sidelined. Linebacker Fred Warner and defensive lineman Nick Bosa are on injured reserve due to surgeries. Wide receiver Brandon Aiyuk remains on the physically unable to perform list, with hopes of a late-season return. Fullback Kyle Juszczyk is questionable with rib injuries but practiced limitedly. Cornerback Tre Tomlinson and running back Patrick Taylor Jr. are out for the season due to injuries. These injuries could hamper the 49ers' defensive and offensive capabilities, influencing game dynamics.
Understanding these player statuses, including detailed injury notes and return timelines, is vital to making smart betting decisions. Bettors can leverage this injury report alongside other NFL injury updates on the league injuries page to gain an edge. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
![]() Tampa Bay 7-641% -4½ -110Caesars | |||||||
![]() Houston 8-518% -9 -114SugarHouse | |||||||
Philadelphia 8-515% -10½ -115SugarHouse | |||||||
Jacksonville 9-429% -12½ -115SugarHouse | |||||||
![]() Chicago 9-413% -7½ -109BetRivers | |||||||
New England 11-255% +1½ -115FanDuel | |||||||
![]() Cincinnati 4-930% +2½ -105BetMGM | |||||||
![]() Kansas City 6-755% -5½ -105FanDuel | |||||||
![]() N.Y. Giants 2-1145% -2½ -110BetMGM | |||||||
Seattle 10-314% -13½ -113Caesars | |||||||
Denver 11-228% +2½ -110BetMGM | |||||||
New Orleans 3-1062% +3 -121SugarHouse | |||||||
![]() L.A. Rams 10-355% -5½ -114BetRivers | |||||||
![]() San Francisco 9-44% -12½ -110Bet365 | |||||||
Dallas 6-6-123% -5½ -110Bet365 | |||||||
![]() Pittsburgh 7-629% -3½ -105BetMGM |
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