Dec 14, 2025 4:25 PM EST

Week 15

Tennessee

9-4

San Francisco

-12½ (-114)o44½ (-112)

FOX

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Tennessee Titans vs San Francisco 49ers Picks

Updated:Dec 11, 2025 1:31 AM EST

The upcoming NFL clash on December 14, 2025, between the Tennessee Titans and San Francisco 49ers at Levi's Stadium in Santa Clara, CA, promises an exciting Sunday football showdown. This game will be broadcast on FOX, providing fans nationwide a chance to catch all the action live. Our detailed picks and predictions suggest a competitive game with the 49ers favored to win 28-17 against the Titans. The predicted total score is just over 45 points, making the over 44.5 a notable betting option.

In recent games, our prediction model has shown strength in the 2-way market, boasting an impressive hit rate of 81.4% for San Francisco wins, and a profitable point spread hit rate of 55.2% for Tennessee covering the +12.5 spread. These statistics provide valuable betting tips that can help bettors make informed decisions. For this game, we recommend considering the moneyline on San Francisco and the point spread on Tennessee for a balanced betting strategy.

For bettors looking to maximize value, our model suggests the over 44.5 total points as a high expected value (EV) bet, supported by a 49.1% coverage percentage. This insight, combined with our comprehensive NFL picks, can boost your betting confidence. Explore more expert picks and predictions on our NFL picks page and get ahead with smart parlays and bets. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

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ODDS PICKS PLAYER PROPS FUTURES PLAYER FUTURES INJURIES WEATHER RANKINGS STANDINGS

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Personalize your notifications and get updates on the teams, players or events you care about most. THU 12/118:15 PM Atlanta 4-9 59% +5 -118BetMGM
Tampa Bay 7-6 41% -4½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Arizona 3-10 82% +10 -110Bet365
Houston 8-5 18% -9 -114SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Las Vegas 2-11 85% +11½ -105FanDuel
Philadelphia 8-5 15% -10½ -115SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM N.Y. Jets 3-10 71% +13½ -114Caesars
Jacksonville 9-4 29% -12½ -115SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Cleveland 3-10 87% +7½ -110Caesars
Chicago 9-4 13% -7½ -109BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Buffalo 9-4 45% -1 -110Caesars
New England 11-2 55% +1½ -115FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Baltimore 6-7 70% -2½ -110Bet365
Cincinnati 4-9 30% +2½ -105BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM L.A. Chargers 9-4 45% +6 -115BetRivers
Kansas City 6-7 55% -5½ -105FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Washington 3-10 55% +2½ -105Bet365
N.Y. Giants 2-11 45% -2½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/144:25 PM Indianapolis 8-5 86% +14 -110Bet365
Seattle 10-3 14% -13½ -113Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/144:25 PM Green Bay 9-3-1 72% -2 -110Bet365
Denver 11-2 28% +2½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/144:25 PM Carolina 7-6 38% -2½ -115Caesars
New Orleans 3-10 62% +3 -121SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/144:25 PM Detroit 8-5 45% +6 -108Caesars
L.A. Rams 10-3 55% -5½ -114BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/144:25 PM Tennessee 2-11 96% +13 -114BetRivers
San Francisco 9-4 4% -12½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/148:20 PM Minnesota 5-8 77% +6½ -115FanDuel
Dallas 6-6-1 23% -5½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. MON 12/158:15 PM Miami 6-7 71% +3½ -110Bet365
Pittsburgh 7-6 29% -3½ -105BetMGM

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