Dec 14, 2025 4:25 PM EST

Week 15

Tennessee

9-4

San Francisco

-12½ (-114)o44½ (-112)

FOX

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Tennessee Titans vs San Francisco 49ers Odds

Updated:Dec 11, 2025 1:13 AM EST

The upcoming NFL clash on December 14, 2025, between the Tennessee Titans and the San Francisco 49ers promises an exciting Sunday football showdown at Levi's Stadium in Santa Clara, CA. This Week 15 regular season game attracts attention with the 49ers favored by a substantial point spread of -12½ -114, while the Titans are the underdogs at +12½ -106, according to Caesars sportsbook. The opening odds have remained consistent, indicating steady confidence in the 49ers' strong home advantage.

For bettors, understanding the point spread and current odds is crucial to making informed wagers. The over/under total is set at 44½ with the over favored at -112. This provides a clear framework for betting lines and totals that can help bettors strategize effectively.

Fans can watch this exciting NFL Sunday football game on FOX, making it easy to follow the action live. For those looking to sharpen their betting edge, consider starting your OddsTrader Turbo subscription or place your bet with a trusted U.S. regulated sportsbook like Caesars to maximize your potential returns.

Explore more NFL odds and betting insights on our NFL odds page to stay ahead of the game and make smarter bets all season long.

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ODDS PICKS PLAYER PROPS FUTURES PLAYER FUTURES INJURIES WEATHER RANKINGS STANDINGS

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This Week

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Personalize your notifications and get updates on the teams, players or events you care about most. THU 12/118:15 PM Atlanta 4-9 59% +5 -118BetMGM
Tampa Bay 7-6 41% -4½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Arizona 3-10 82% +10 -110Bet365
Houston 8-5 18% -9 -114SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Las Vegas 2-11 85% +11½ -105FanDuel
Philadelphia 8-5 15% -10½ -115SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM N.Y. Jets 3-10 71% +13½ -114Caesars
Jacksonville 9-4 29% -12½ -115SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Cleveland 3-10 87% +7½ -110Caesars
Chicago 9-4 13% -7½ -109BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Buffalo 9-4 45% -1 -110Caesars
New England 11-2 55% +1½ -115FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Baltimore 6-7 70% -2½ -110Bet365
Cincinnati 4-9 30% +2½ -105BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM L.A. Chargers 9-4 45% +6 -115BetRivers
Kansas City 6-7 55% -5½ -105FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Washington 3-10 55% +2½ -105Bet365
N.Y. Giants 2-11 45% -2½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/144:25 PM Indianapolis 8-5 86% +14 -110Bet365
Seattle 10-3 14% -13½ -113Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/144:25 PM Green Bay 9-3-1 72% -2 -110Bet365
Denver 11-2 28% +2½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/144:25 PM Carolina 7-6 38% -2½ -115Caesars
New Orleans 3-10 62% +3 -121SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/144:25 PM Detroit 8-5 45% +6 -108Caesars
L.A. Rams 10-3 55% -5½ -114BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/144:25 PM Tennessee 2-11 96% +13 -114BetRivers
San Francisco 9-4 4% -12½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/148:20 PM Minnesota 5-8 77% +6½ -115FanDuel
Dallas 6-6-1 23% -5½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. MON 12/158:15 PM Miami 6-7 71% +3½ -110Bet365
Pittsburgh 7-6 29% -3½ -105BetMGM

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