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The Buffalo Bills are set to face the San Francisco 49ers at Highmark Stadium in Orchard Park, NY on December 1, 2024, at 20:20 EST. This NFL Week 13 matchup is drawing significant attention, especially after the Bills' recent victory against the Kansas City Chiefs, where they secured a 30-21 win. The Bills have a strong home record, which you can see on our NFL standings page. Buffalo's offense, led by quarterback Josh Allen, has been a force, averaging 345.3 total yards per game. Meanwhile, the 49ers, struggling with a 5-6 record, are looking to bounce back after a heavy 38-10 loss to the Green Bay Packers. The 49ers' quarterback situation remains uncertain with Brock Purdy listed as questionable, though reports suggest he may start. The point spread for this game is -6 in favor of the Bills, highlighting their home-field advantage. Fans can catch the game live on NBC.
In their last matchup on December 7, 2020, the Bills triumphed over the 49ers with a final score of 34-24. This historical context, combined with the current odds and stats, provides a comprehensive view for bettors.