Atlanta Falcons vs Arizona Cardinals Betting Trends

The upcoming NFL showdown on December 21, 2025, features the Atlanta Falcons visiting the Arizona Cardinals at State Farm Stadium in Glendale, AZ. This Sunday football game promises to be an intense battle as both teams look to improve their records in the 2025-26 season. The Falcons come in as slight favorites with a -3 point spread and are expected to cover against the Cardinals, who have struggled at home with a 1-6 ATS record. The total points line is set at 48.5, with the under favored, indicating a potentially defensive battle.

Arizona's starting quarterback Kyler Murray, listed as probable, brings a dynamic passing game averaging 238.4 yards per game with a balanced attack that includes 20.5 rushing first downs per game. Their defense, however, ranks strong in pass defense but has been vulnerable against the run, conceding 127.9 rushing yards per game. The Falcons' offense, led by quarterback Kirk Cousins, averages 217.7 passing yards with a more run-heavy approach, generating 122.7 rushing yards per game. Atlanta's defense is stout against the pass but less effective against the run, giving up 124.5 rushing yards per game. This matchup of pass offense versus pass defense and run offense versus run defense will be key in determining the outcome.

Injuries could play a role as Arizona has a few questionable players like Kedon Slovis and Michael Harrison Jr., while Atlanta has key players like Drake London and Kyle Pitts Sr. questionable. The Falcons have been more successful ATS on the road (5-3) compared to the Cardinals' poor home ATS performance (1-6). This insight, combined with the odds and recent performances, suggests a lean towards the Falcons covering the spread.

For bettors looking to dive deeper into betting trends and game insights for Atlanta Falcons vs Arizona Cardinals, the matchup will be broadcast on FOX, providing fans and bettors with ample opportunity to watch and wager smartly. The best odds available today for Atlanta are -3 at -107 at Caesars and for Arizona +3 at -113 also at Caesars. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

For a look back at their last intense matchup on November 12, 2023, when the Cardinals edged out the Falcons 25-23, check out the detailed recap on our previous game page. This close history adds intrigue to the upcoming contest.