Buffalo Bills vs Cleveland Browns Betting Trends

The upcoming NFL clash on December 21, 2025, between the Buffalo Bills and Cleveland Browns at Huntington Bank Field in Cleveland, OH, promises an exciting Sunday football showdown. The Bills, led by starting quarterback Josh Allen, come into this game with a strong passing offense averaging 222.7 yards per game, while the Browns, starting Dillon Gabriel at quarterback, have a solid pass defense allowing just 169 yards on average. This matchup highlights a classic pass offense versus pass defense battle that bettors should closely watch.

Buffalo's run offense is robust, averaging 158.5 rushing yards per game, which will be tested by Cleveland's run defense that allows 110.1 yards on average. Conversely, Cleveland's offense struggles a bit more, averaging only 264.3 total yards per game, compared to Buffalo's 381.2 yards. The Browns' pass protection will be challenged by Buffalo's aggressive pass rush, led by defensive ends Joey Bosa and A.J. Epenesa, who have combined for multiple sacks this season.

Injuries could play a role in this contest. Buffalo's Cam Lewis is questionable but likely to play, while Cleveland's key defensive end Myles Garrett is fully participating in practice, signaling readiness. The point spread currently favors the Bills by 10.5 points, with an over/under of 41.5 total points. These betting trends suggest Buffalo is the favorite to cover the spread, but Cleveland's home advantage could keep the game competitive.

Buffalo has a 10-4 straight-up record this season and splits 7-7 against the spread, while Cleveland struggles at 3-11 straight-up with a 5-9 ATS record. The Browns' home ATS record is slightly better at 4-3. For bettors, understanding these stats and the matchup dynamics will be crucial. The game will be broadcast on CBS, making it easy to watch and wager live.

In their last matchup on November 20, 2022, the Buffalo Bills defeated the Cleveland Browns 31-23, a game that went over the total points line of 50.5. That game is a good reference for bettors looking for trends and insights. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.