Sep 21, 2025 4:25 PM EDT

Week 3

Arizona

2-0

San Francisco

-2½ (-110)o45½ (-110)

FOX

MATCHUP PREDICTION ODDS BOOSTS PLAYER PROPS GAME PROPS INJURIES WEATHER

Event NotificationsStay on top of the action with alerts for game start, scoring, odds updates, predictions and more.

Don't show me this again

Arizona Cardinals vs San Francisco 49ers Odds

Updated:Sep 21, 2025 3:41 AM EDT

Get ready for a thrilling Sunday football showdown on September 21, 2025, as the Arizona Cardinals take on the San Francisco 49ers at Levi's Stadium in Santa Clara, CA. This NFL clash promises to be a captivating battle, with the 49ers currently favored by a -2 spread at odds of -110, as per Caesars. The Cardinals, however, are not to be underestimated with a +2 underdog spread at -110. The game kicks off at 4:25 PM ET, and you can catch all the action live on Fox.

For those looking to place a bet, the current odds show the 49ers as the favorites with a moneyline of -135, while the Cardinals stand at +115. The over/under is set at 45.5, and given the offensive potential of both teams, the over at -110 could be an enticing option. If you're looking to make the most of your bets, consider starting your OddsTrader Turbo subscription here.

Stay updated with the latest NFL odds to make informed betting decisions. Remember, the insights provided can give you the edge you need. Whether you're betting on the point spread or the moneyline, this game is sure to be a nail-biter!

What are the betting odds for Arizona Cardinals vs San Francisco 49ers?

Spread (FULL GAME)

EXPECTED VALUECOVER PROB.EXPECTED VALUEBEST LINE

ArizonaSpread

+18.9%

San FranciscoSpread

-22.2%

MONEYLINE (FULL GAME)

EXPECTED VALUECOVER PROB.EXPECTED VALUEBEST LINE

ArizonaMONEYLINE

+20.9%

San FranciscoMONEYLINE

-23.8%

EXCLUSIVE BOOSTS

Trey McBride & Marvin Harrison Jr. Each Over 49.5 Receiving YardsTrey McBride Over 49.5 Receiving Yards; Marvin Harrison Jr. Over 49.5 Receiving Yards

Kyler Murray Over 1.5 Pass TDs & Over 29.5 Rush YardsKyler Murray Over 1.5 Pass TDs & Over 29.5 Rush Yards

Christian McCaffrey Over 149.5 Rush + Receiving Yards & TDChristian McCaffrey Over 149.5 Rush + Receiving Yards & TD

3 Total BoostsFor This Event

Total (FULL GAME)

EXPECTED VALUECOVER PROB.EXPECTED VALUEBEST LINE

OVERTotal

+3.6%

UNDERTotal

-5.7%

Spread (1H)

BEST LINE

ArizonaSpread

San FranciscoSpread

MONEYLINE (1H)

BEST LINE

ArizonaMONEYLINE

San FranciscoMONEYLINE

Total (1H)

BEST LINE

OVERTotal

UNDERTotal

Spread (2H)

BEST LINE

ArizonaSpread

San FranciscoSpread

MONEYLINE (2H)

BEST LINE

ArizonaMONEYLINE

San FranciscoMONEYLINE

DRAWMONEYLINE

Total (2H)

BEST LINE

OVERTotal

UNDERTotal

Spread (1Q)

BEST LINE

ArizonaSpread

San FranciscoSpread

MONEYLINE (1Q)

BEST LINE

ArizonaMONEYLINE

San FranciscoMONEYLINE

Total (1Q)

BEST LINE

OVERTotal

UNDERTotal

Spread (2Q)

BEST LINE

ArizonaSpread

San FranciscoSpread

MONEYLINE (2Q)

BEST LINE

ArizonaMONEYLINE

San FranciscoMONEYLINE

Total (2Q)

BEST LINE

OVERTotal

UNDERTotal

Spread (3Q)

BEST LINE

ArizonaSpread

San FranciscoSpread

MONEYLINE (3Q)

BEST LINE

ArizonaMONEYLINE

San FranciscoMONEYLINE

Total (3Q)

BEST LINE

OVERTotal

UNDERTotal

Spread (4Q)

BEST LINE

ArizonaSpread

San FranciscoSpread

MONEYLINE (4Q)

BEST LINE

ArizonaMONEYLINE

San FranciscoMONEYLINE

Total (4Q)

BEST LINE

OVERTotal

UNDERTotal

The best odds available today for Arizona is +2½ -110 at BetMGM and for San Francisco -2 -109 at BetRivers. The total for the over/under line is o44½ -114 at FanDuel.

NFL

ODDS PICKS PLAYER PROPS FUTURES PLAYER FUTURES INJURIES WEATHER RANKINGS STANDINGS

Spread

Spread
Money
Total
Merged

Game

Game
1H
2H
1Q
2Q
3Q
4Q

This Week

Last Week

Personalize your notifications and get updates on the teams, players or events you care about most. SUN 09/211:00 PM Indianapolis 2-0 28% -4½ -110BetMGM
Tennessee 0-2 72% +5 -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 09/211:00 PM Atlanta 1-1 27% -4½ -110Bet365
Carolina 0-2 73% +5½ -115BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 09/211:00 PM Las Vegas 1-1 56% +3 -115BetMGM
Washington 1-1 44% -3 +100Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 09/211:00 PM Green Bay 2-0 19% -7½ -104FanDuel
Cleveland 0-2 81% +7½ -110BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 09/211:00 PM Cincinnati 2-0 50% +3 -110Bet365
Minnesota 1-1 50% -3 -105BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 09/211:00 PM L.A. Rams 2-0 54% +3½ -115Caesars
Philadelphia 2-0 46% -3½ -104FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 09/211:00 PM Pittsburgh 1-1 38% -1½ -110Caesars
New England 1-1 62% +2 -112BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 09/211:00 PM N.Y. Jets 0-2 79% +6½ -107BetRivers
Tampa Bay 2-0 21% -6½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 09/211:00 PM Houston 0-2 39% +1½ -108BetRivers
Jacksonville 1-1 61% -1½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 09/214:05 PM Denver 1-1 69% +3 -115FanDuel
L.A. Chargers 2-0 31% -2½ -118BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 09/214:05 PM New Orleans 0-2 82% +7½ -122FanDuel
Seattle 1-1 18% -7 -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 09/214:25 PM Dallas 1-1 16% -1 -120BetMGM
Chicago 0-2 84% +1½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 09/214:25 PM Arizona 2-0 54% +2½ -110BetMGM
San Francisco 2-0 46% -2 -109BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 09/218:20 PM Kansas City 0-2 25% -5½ -115FanDuel
N.Y. Giants 0-2 75% +6½ -114BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. MON 09/228:15 PM Detroit 1-1 68% +5½ -115FanDuel
Baltimore 1-1 32% -4½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTHU 09/188:15 PM Miami 0-3 21 +12 -110BetRivers
Buffalo 3-0 31 -11 -110Bet365

Download the app

NFL

Report

OddsTrader App Blog Privacy Policy DMCA

The content on this site is for entertainment purposes only. OddsTrader makes no representation or warranty as to the accuracy of the information given or the outcome of any game or event. Please be aware of and respect the laws regarding sports betting for your jurisdiction as they vary from state to state. OddsTrader does not target underaged persons. Using this information to contravene any law or statute is prohibited. This site contains commercial content, and OddsTrader may be compensated for the links provided on this site.Disclosure.

OddsTrader is licensed to operate in NJ, NY, PA, IN, CO, IA, IL, VA, WV, TN, CT, MI, AZ, LA, WY, OR, KS, DC, MA & OH.

Seek help with a gambling addiction at 1-800-Gambler.

OddsTrader uses cookies to help us provide, protect & improve our services. See ourPrivacy Policyfor more details.

ACCEPT & CLOSE