Buffalo Bills vs Cleveland Browns Injury Report

The upcoming NFL matchup on December 21, 2025, between the Buffalo Bills and Cleveland Browns at Huntington Bank Field in Cleveland, OH, offers a thrilling Sunday football experience for fans and bettors alike. This game, broadcast on CBS, is highly anticipated as both teams look to secure a crucial win in Week 16 of the 2025-26 NFL season.

In terms of player injuries, the Cleveland Browns face significant challenges. Key players such as Deshaun Watson (QB) are out for the season with an Achilles injury, and several others including Jack Conklin (Tackle) and Wyatt Teller (Guard) are sidelined. Joel Bitonio (Guard) and Cedric Tillman (Wide Receiver) are questionable, potentially impacting the Browns' offensive and defensive strategies. Meanwhile, the Buffalo Bills enter the game with a relatively healthier roster, but still have players like Joshua Palmer (WR) and Terrel Bernard (LB) listed as questionable. The injury report reveals that while some players are limited in practice, most are expected to participate, which could influence the game's dynamics and betting odds.

Understanding these player statuses is crucial for bettors aiming to make informed wagers. Injuries to core players can affect team performance and game outcomes, making the injury report an essential tool for smart betting decisions. For more detailed injury updates, bettors can refer to the NFL injury list for the latest player statuses. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.