Dec 21, 2025 1:00 PM EST

Week 16

Buffalo

3-11

Cleveland

BUF

-10 (-110)o42½ (-110)

CBS

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Buffalo Bills vs Cleveland Browns Picks

Updated:Dec 16, 2025 1:32 AM EST

The upcoming NFL showdown between the Buffalo Bills and Cleveland Browns is set for December 21, 2025, at Huntington Bank Field in Cleveland, OH. This Sunday football game promises plenty of excitement and betting opportunities for fans and sports bettors alike. Scheduled to be broadcast on CBS, this game offers a prime chance to capitalize on expert picks and betting tips.

Our prediction model favors the Buffalo Bills with a predicted score of 27 to the Cleveland Browns' 14, suggesting a strong Bills victory with a -10 point spread. This aligns with our profitable point spread market, which has a hit rate of 56.7% and an expected value (EV) of 3.2% in recent games. The total points are expected to go under 42.5, with a predicted total score of approximately 41. The under bet also shows a positive EV of 1.2% and a 53.6% hit rate, making it a smart betting choice.

Our picks have been successful in recent NFL matchups, showing a consistent ability to identify value bets and profitable parlays. This game is no exception, and bettors should consider the insights provided to make informed wagering decisions. For more detailed analysis and additional NFL picks, visit our NFL picks page.

Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

Which team is favored to win?

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ODDS PICKS PLAYER PROPS FUTURES PLAYER FUTURES INJURIES WEATHER RANKINGS STANDINGS

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This Week

Last Week

Personalize your notifications and get updates on the teams, players or events you care about most. THU 12/188:15 PM L.A. Rams 11-3 37% -½ -112BetRivers
Seattle 11-3 63% +1½ -120FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 12/205:00 PM Philadelphia 9-5 24% -6½ -109Caesars
Washington 4-10 76% +6½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 12/208:20 PM Green Bay 9-4-1 71% -1 -109Caesars
Chicago 10-4 29% +2 -118BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/211:00 PM Buffalo 10-4 5% -10 -110Bet365
Cleveland 3-11 95% +10½ -122FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/211:00 PM N.Y. Jets 3-11 0% +4½ -112BetRivers
New Orleans 4-10 100% -4 -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/211:00 PM Minnesota 6-8 29% -2½ -118BetRivers
N.Y. Giants 2-12 71% +3 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/211:00 PM Tampa Bay 7-7 42% -3 -105Bet365
Carolina 7-7 58% +3 -110FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/211:00 PM Kansas City 6-8 33% -3 -115Bet365
Tennessee 2-12 67% +3½ -108Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/211:00 PM L.A. Chargers 10-4 18% +2 -109BetRivers
Dallas 6-7-1 82% -1½ -115BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/211:00 PM Cincinnati 4-10 0% +1 -112BetRivers
Miami 6-8 100% +1½ -120Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/214:05 PM Atlanta 5-9 57% -2½ -110Caesars
Arizona 3-11 43% +2½ -105Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/214:05 PM Jacksonville 10-4 53% +3 -110Caesars
Denver 12-2 47% -3 -108BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/214:25 PM Pittsburgh 8-6 89% +7 -110Bet365
Detroit 8-6 11% -6½ -114FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/214:25 PM Las Vegas 2-12 89% +14½ -112Caesars
Houston 9-5 11% -14½ -104FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/218:20 PM New England 11-3 52% +3 -113Caesars
Baltimore 7-7 48% -2½ -120BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. MON 12/228:15 PM San Francisco 10-4 26% -5½ -117Caesars
Indianapolis 8-6 74% +6 -110Bet365

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