Buffalo Bills vs Cleveland Browns Game Props

The highly anticipated NFL matchup on December 21, 2025, features the Buffalo Bills facing off against the Cleveland Browns at Huntington Bank Field in Cleveland, OH. This Sunday football game offers a compelling betting opportunity with exciting game props to explore.

The Bills bring a strong pass offense that will be tested against the Browns' solid pass defense, while Cleveland's run offense will face a tough run defense from Buffalo. The battle between pass protection and pass rush on both sides will be a key factor influencing the pace and flow of the game. These dynamics are crucial for bettors considering totals, touchdowns, and field goals markets.

Our recent game projections and prop bets have shown a high hit rate and positive expected value, especially in player touchdown markets. For this game, look out for James Cook III as a promising first touchdown scorer with a strong EV and impressive hit rate, making it a standout prop bet. Our projections have been profitable in the last 10 games, giving bettors an edge in making smart wagers.

This game will be broadcast on CBS, allowing fans to enjoy the action live. For those looking to maximize their betting strategy, consider our detailed player props analysis. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.