San Francisco 49ers vs Cleveland Browns Injury Report

The upcoming clash on November 30, 2025, between the San Francisco 49ers and Cleveland Browns at Huntington Bank Field in Cleveland, OH, is one NFL game to watch closely, especially with the latest injury report impacting both teams.

The Browns are significantly impacted by injuries, with key players like wide receiver DeAndre Carter on injured reserve due to a knee injury and tight end David Njoku listed as questionable with a knee issue. Quarterback Deshaun Watson remains on the Physically Unable to Perform-Reserve list after Achilles surgery, expected to return in early December. Cornerbacks Denzel Ward and Tyson Campbell are questionable due to migraine and hip injuries respectively, which could affect the Browns' defensive stability. Several other Browns players, including linebacker Jeremiah Owusu-Koramoah and running back Jerome Ford, are also listed with injuries that could influence the team's performance.

On the San Francisco 49ers side, notable absences include linebacker Fred Warner and defensive lineman Nick Bosa, both on injured reserve following surgeries. Wide receiver Brandon Aiyuk is on the Physically Unable to Perform-Reserve list, recovering from knee surgery. The 49ers also have several players marked questionable, such as kicker Eddy Pineiro and linebacker Luke Gifford, who could impact special teams and defensive plays. These injuries could affect the 49ers' ability to execute their game plan fully.

Understanding these player statuses is crucial for bettors looking to make informed wagers. The injury report reveals vulnerabilities and potential shifts in team dynamics that can influence game outcomes. Bettors should consider these factors when evaluating odds and placing bets. For comprehensive updates, check the NFL injury report page and for a competitive edge, consider starting an OddsTrader Turbo subscription or placing your bet with a U.S. regulated sportsbook.