San Francisco 49ers vs Cleveland Browns Game Props

The upcoming NFL showdown on November 30, 2025, at Huntington Bank Field in Cleveland, OH, features the San Francisco 49ers vs Cleveland Browns in an exciting regular season Week 13 matchup. Broadcast on CBS, this game promises thrilling Sunday football action filled with strategic plays and betting opportunities. Bettors should keep an eye on the game props, especially the player to score the first touchdown, which often provides lucrative value.

The San Francisco 49ers boast a strong pass offense that will challenge the Browns' pass defense, while the Browns' run offense faces a stout 49ers run defense. The 49ers' pass protection is solid but will be tested by the Browns' aggressive pass rush, making for a dynamic clash of styles. Our game projections suggest a fast-paced contest with multiple scoring opportunities, including touchdowns and field goals.

Our prop bet analysis highlights Christian McCaffrey as a favorite to score the first touchdown with a high hit rate and positive EV, making him a smart pick for bettors. Over the last 10 games, our projections on player props have yielded consistent profits, especially in markets like first touchdown scorers and team props. Understanding these stats can help bettors make informed decisions and capitalize on favorable odds.

Don't miss out on this NFL game props action between the San Francisco 49ers and Cleveland Browns. For detailed player prop insights, check out our NFL player props page. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.