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Nov 30, 2025 1:00 PM EST
Week 13
SF
-5½ (-110)o36½ (-105)
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San Francisco 49ers vs Cleveland Browns Picks
Updated:Nov 26, 2025 1:12 AM EST
The upcoming NFL clash on November 30, 2025, between the San Francisco 49ers and Cleveland Browns at Huntington Bank Field in Cleveland, OH, promises an exciting Sunday football showdown. This Week 13 game will be broadcast on CBS, offering fans a thrilling viewing experience.
Our picks favor the San Francisco 49ers with a predicted score of 23 to 15 over the Cleveland Browns. The 49ers are expected to cover the spread at -5, boasting a solid 56.6% hit rate and a positive EV of 4.9%, making this a smart bet for fans looking to capitalize on betting tips. Meanwhile, the predicted total score of 37.853 suggests the under 38.5 is a safer play, supported by a 51.4% hit rate and a slight negative EV, indicating a low-scoring game.
Our prediction model has been profitable in the last 10 games, winning 6 of them on point spread bets, which adds confidence to these picks. Bettors can leverage these insights to make informed decisions and increase their chances of winning. For more expert NFL picks and predictions, check out our comprehensive NFL picks page.
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UPCOMING GAME PREDICTION
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OTHER BETS
Sun 11/30 1:00 PMSF @ CLE
Shedeur SandersPassing Attempts
EV
+19.5%
+19.5%
Christian McCaffreyRushing + Receiving Yards
EV
+18.3%
+18.3%
Christian McCaffreyAnytime Touchdown Scorer
EV
+15.8%
+15.8%
Jauan JenningsAnytime Touchdown Scorer
EV
+12.8%
+12.8%
Shedeur SandersPlayer Longest Passing Completion
EV
+10.8%
+10.8%
Shedeur SandersRushing Yards
EV
+9.4%
+9.4%
Brian Robinson Jr.Anytime Touchdown Scorer
EV
+9.2%
+9.2%
David NjokuAnytime Touchdown Scorer
EV
+8.6%
+8.6%
Brock PurdyPlayer Longest Passing Completion
EV
+7.8%
+7.8%
Christian McCaffreyReceiving Yards
EV
+7.6%
+7.6%
NFL
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This Week
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NFLWeek 13
 Detroit 7-431% -2½ -120BetRivers | |||||||
 Dallas 5-5-170% +3½ -112Caesars | |||||||
 Baltimore 6-522% -7 -110Bet365 | |||||||
 Philadelphia 8-332% -7 -105Bet365 | |||||||
 Indianapolis 8-346% -3½ -110Bet365 | |||||||
 Tampa Bay 6-537% -2½ -110Bet365 | |||||||
 Tennessee 1-1076% +6½ -106FanDuel | |||||||
 Carolina 6-651% +10½ -110Bet365 | |||||||
 Miami 4-737% -5½ -113BetRivers | |||||||
 N.Y. Jets 2-973% +3 -125BetMGM | |||||||
 Cleveland 3-822% +5½ -118BetMGM | |||||||
 Seattle 8-367% -10½ -105FanDuel | |||||||
 Pittsburgh 6-583% +3½ -110BetMGM | |||||||
 L.A. Chargers 7-410% -9 -114SugarHouse | |||||||
 Washington 3-831% +6 -114BetRivers | |||||||
 New England 10-215% -7 -118BetRivers |
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