Nov 30, 2025 1:00 PM EST

Week 13

San Francisco

3-8

Cleveland

-5 (-110)o36½ (-105)

CBS

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49ers vs Browns Odds for NFL Game

Updated:Nov 27, 2025 1:47 AM EST

The upcoming NFL showdown between the San Francisco 49ers and the Cleveland Browns is set for November 30, 2025, at Huntington Bank Field in Cleveland, OH. This Sunday football game is a must-watch for bettors and fans alike as the 49ers enter as favorites with a point spread of -4½ -113, while the Browns are the underdogs at +4½ -107. The opening odds showed the 49ers also at -4½, indicating consistent confidence in their edge. The total points line is set at 36½, with the under favored at -128, suggesting a potentially defensive battle.

Watching this game on CBS will provide fans with top-tier NFL action. Bettors can leverage the current odds and betting lines to make informed wagers. The San Francisco 49ers have been strong contenders this season, and their performance against the Browns at Huntington Bank Field will be critical. The Cleveland Browns, while underdogs, have the potential to upset the odds, making the betting lines dynamic and engaging.

For those looking to stay ahead, checking the latest NFL odds can provide valuable insights. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge. For more detailed NFL betting options, visit our NFL odds page.

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ODDS PICKS PLAYER PROPS FUTURES PLAYER FUTURES INJURIES WEATHER RANKINGS STANDINGS

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Personalize your notifications and get updates on the teams, players or events you care about most. THU 11/271:00 PM Green Bay 7-3-1 69% +3 -110Bet365
Detroit 7-4 31% -2½ -120BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. THU 11/274:30 PM Kansas City 6-5 30% -3 -115Bet365
Dallas 5-5-1 70% +3½ -112Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. THU 11/278:20 PM Cincinnati 3-8 78% +7½ -115BetMGM
Baltimore 6-5 22% -7 -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. FRI 11/283:00 PM Chicago 8-3 68% +7 -110BetMGM
Philadelphia 8-3 32% -7 -105Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/301:00 PM Houston 6-5 54% +4½ -114BetRivers
Indianapolis 8-3 46% -3½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/301:00 PM Arizona 3-8 63% +3 -118BetRivers
Tampa Bay 6-5 37% -2½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/301:00 PM Jacksonville 7-4 26% -6½ -110Caesars
Tennessee 1-10 74% +6½ -106FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/301:00 PM L.A. Rams 9-2 49% -10½ -105BetMGM
Carolina 6-6 51% +10½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/301:00 PM New Orleans 2-9 63% +5½ -105Bet365
Miami 4-7 37% -5½ -113BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/301:00 PM Atlanta 4-7 27% -2½ -115Bet365
N.Y. Jets 2-9 73% +3 -125BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/301:00 PM San Francisco 8-4 78% -4½ -110BetRivers
Cleveland 3-8 22% +5½ -118BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/304:05 PM Minnesota 4-7 33% +11½ -105Caesars
Seattle 8-3 67% -10½ -105FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/304:25 PM Buffalo 7-4 17% -3 -120Bet365
Pittsburgh 6-5 83% +3½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/304:25 PM Las Vegas 2-9 90% +10 -120BetMGM
L.A. Chargers 7-4 10% -9 -114SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/308:20 PM Denver 9-2 69% -5½ -110Bet365
Washington 3-8 31% +6 -114BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. MON 12/018:15 PM N.Y. Giants 2-10 85% +7½ -115Caesars
New England 10-2 15% -7 -118BetRivers

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