Oct 5, 2025 1:00 PM EDT

Week 5

Las Vegas

3-1

Indianapolis

IND

-7 (-118)o48 (-109)

FOX

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Raiders vs Colts Picks & Predictions

Updated:Oct 5, 2025 2:44 AM EDT

As we gear up for the thrilling NFL showdown on October 5, 2025, between the Las Vegas Raiders and Indianapolis Colts at Lucas Oil Stadium in Indianapolis, IN, fans and bettors alike are buzzing with anticipation. This Sunday football clash promises to be a spectacle, with the Colts favored to win. Our top pick for this matchup is leaning towards Indianapolis, who have a predicted score of 27 against the Raiders' 20. With the Colts' strong home advantage and a 72.8% win probability, they are poised to cover the spread. Our prediction model has a solid track record, especially in point spread bets, making it a smart choice for anyone looking to place a wager. The game will be broadcasted on FOX, so make sure to tune in. For more NFL insights, check out our NFL picks page to stay ahead of the game. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook.

What is the best bet for the Raiders vs Colts game?

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Personalize your notifications and get updates on the teams, players or events you care about most. SUN 10/059:30 AM Minnesota 2-2 37% -3½ -102Caesars
Cleveland 1-3 63% +3½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 10/051:00 PM Miami 1-3 37% -1 -110Bet365
Carolina 1-3 63% +1½ -110BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 10/051:00 PM Dallas 1-2-1 23% -1½ -110Bet365
N.Y. Jets 0-4 77% +1½ -105FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 10/051:00 PM Las Vegas 1-3 69% +7½ -115BetMGM
Indianapolis 3-1 31% -7 -110FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 10/051:00 PM Denver 2-2 67% +4½ -118FanDuel
Philadelphia 4-0 33% -4 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 10/051:00 PM N.Y. Giants 1-3 51% +2 -110Bet365
New Orleans 0-4 49% -1½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 10/051:00 PM Houston 1-3 66% -1 -113BetRivers
Baltimore 1-3 34% +2 -120BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 10/054:05 PM Tennessee 0-4 68% +8½ -118FanDuel
Arizona 2-2 32% -7½ -109BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 10/054:05 PM Tampa Bay 3-1 35% +4 -110BetRivers
Seattle 3-1 65% -3½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 10/054:25 PM Detroit 3-1 16% -10 -113Caesars
Cincinnati 2-2 84% +10½ -114BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 10/054:25 PM Washington 2-2 58% +3 -110BetMGM
L.A. Chargers 3-1 42% -2½ -120FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 10/058:20 PM New England 2-2 78% +8½ -112FanDuel
Buffalo 4-0 22% -8 -105Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. MON 10/068:15 PM Kansas City 2-2 17% -3 -118FanDuel
Jacksonville 3-1 83% +3½ -115Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FINAL OTTHU 10/028:15 PM San Francisco 4-1 26 +8½ -112BetRivers
L.A. Rams 3-2 23 -7½ -115FanDuel

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