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Dec 14, 2025 4:25 PM EST
Week 15
SF
-12½ (-110)o44½ (-110)
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Betting Trends Tennessee Titans vs San Francisco 49ers
Updated:Dec 13, 2025 1:46 AM EST
The upcoming NFL showdown on December 14, 2025, features the Tennessee Titans visiting the San Francisco 49ers at Levi's Stadium in Santa Clara, CA. This Sunday football matchup promises to be a thrilling contest in the 2025-26 NFL regular season Week 15, showcasing key betting trends and game insights for bettors looking to gain an edge.
San Francisco 49ers, led by starting quarterback Brock Purdy, boast a potent offensive attack averaging 341.15 total yards per game, including a strong passing game with 242.62 yards per game. Their defense is equally impressive, allowing just 335.77 yards and excelling in pass defense and sacks. The 49ers have a solid home record and are favorites with a -12.5 point spread at Caesars, indicating confidence in their ability to dominate at Levi's Stadium.
The Tennessee Titans, with backup QB Cam Horsley stepping in, face challenges on offense, averaging only 246.23 total yards and 161.31 passing yards per game. Their defense allows 350.92 yards per game, slightly higher than the 49ers, but their run defense stands strong. The Titans are underdogs with a +12.5 point spread and can leverage their run game and pass rush to keep the game competitive.
Recent performances show the 49ers winning four of their last five games, with a mix of overs and unders impacting totals around the 44.5 points line. The Titans have struggled with a 2-11 straight-up record but have covered the spread in some recent losses, making them a tricky opponent. Injuries are manageable for both teams, with key players like Christian McCaffrey back for the 49ers and some questionable statuses on the Titans' offensive line and linebacker positions.
Betting trends reveal the 49ers' strong ATS record at home and their ability to control games through balanced offense and defense. The 44.5 total points line suggests a moderately high-scoring game, but the solid defenses on both sides could keep it under control. Bettors should consider the 49ers' home advantage and quarterback stability as a best bet, while also noting the Titans' potential to cover the spread with their run game and pass rush.
For more detailed betting stats and to place smart wagers, check out our OddsTrader Turbo subscription or place your bets with a trusted U.S. regulated sportsbook like Caesars. Don't miss the chance to leverage these insightful betting trends for Tennessee Titans vs San Francisco 49ers on December 14, 2025.
In their last matchup on August 10, 2024, the Tennessee Titans edged out the 49ers 17-13 in a close preseason contest.
ATS Records
All
6-7 (23rd)Against the Spread8-5 (5th)
2-11 (32nd)Straight Up9-4 (10th)
-6.0Straight Up Units+4.5
8-5Over / Under8-5
TEAM MATCHUP
OFF
DEF
OFF
DEF
15.5Points23.6
7.2First Half11.9
8.2Second Half11.8
4.3First Quarter4.6
2.9Second Quarter7.2
3.1Third Quarter4.8
5.2Fourth Quarter6.8
246.2Total Yards341.2
4.8Yards Per Play5.4
161.3Passing Yards242.6
20 - 33.8 (59.1%)Completions-Attempts23.6 - 34.6 (68.2%)
4.3Yards Per Passing Play6.7
3.8 (29)Sacks (Yards)1.5 (11)
84.9Rushing Yards98.5
20.8Attempts28.2
4.1Yards Per Rush3.5
14.81st Downs21.7
9.2Passing13.4
4.4Rushing6.9
1.2Penalties1.4
4.1 / 13.6 (29.9%)3rd Down6.2 / 12.9 (48.2%)
0.8 / 1.9 (44%)4th Down0.8 / 1.3 (58.8%)
0.9 / 1.8 (52.2%)Red Zone2.3 / 3.7 (62.5%)
7.8 (59.2)Penalties (Yards)5.2 (38.4)
1.2Turnovers0.8
0.5Interceptions0.4
0.8Fumbles Lost0.4
58.5Total Plays64.3
4.1Kickoffs5.4
4.2Returns2.8
108Return Yards79.8
26Yards Per Return28
4.9Punts2.9
1.5Returns1.6
27.7Return Yards19.5
18.9Yards Per Return12.1
Priority Injuries
No priority injuries for this team
PRIORITYChristian McCaffrey
FULL PARTICIPATION IN PRACTICE
23 Running Back
Recent Results
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NFLWeek 15
 Houston 8-524% -9 -113BetRivers | |||||||
 Philadelphia 8-59% -11½ -120FanDuel | |||||||
 Jacksonville 9-428% -13 -115Bet365 | |||||||
 Chicago 9-422% -7½ -109BetRivers | |||||||
 New England 11-255% +1½ -114Caesars | |||||||
 Cincinnati 4-955% +2½ -102FanDuel | |||||||
 Kansas City 6-735% -5½ -110Bet365 | |||||||
 N.Y. Giants 2-1129% -2½ -112Caesars | |||||||
 Seattle 10-342% -13½ -115Bet365 | |||||||
 Denver 11-224% +2½ -110BetMGM | |||||||
 New Orleans 3-1071% +3 -117BetRivers | |||||||
 L.A. Rams 10-360% -5½ -117SugarHouse | |||||||
 San Francisco 9-411% -12 -115SugarHouse | |||||||
 Dallas 6-6-130% -5 -118BetMGM | |||||||
 Pittsburgh 7-636% -3 -113Caesars | |||||||
 Tampa Bay 7-728 -5½ -112SugarHouse |
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