Sep 21, 2025 4:25 PM EDT

Week 3

Arizona

2-0

San Francisco

-2½ (-120)o45½ (-110)

FOX

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Arizona Cardinals vs San Francisco 49ers Betting Trends

Updated:Sep 19, 2025 5:05 AM EDT

Before the Arizona Cardinals face off against the San Francisco 49ers on September 21, 2025, fans and bettors alike are gearing up for an exciting clash. This NFL showdown at Levi's Stadium in Santa Clara, CA, promises to be a thrilling encounter between two strong teams. The Cardinals are coming off a recent victory against the Carolina Panthers, while the 49ers secured a win over the New Orleans Saints. With both teams featuring potent offenses and solid defenses, this game is set to be a nail-biter. The starting quarterbacks, Kyler Murray for the Cardinals and Brock Purdy for the 49ers, are both in excellent form, adding to the game's excitement.

The betting trends indicate a close contest, with the 49ers slightly favored with a -2.5 point spread at Caesars. The total points line is set at 45.5, reflecting the expectation of a high-scoring affair. Arizona's pass offense will be tested against San Francisco's robust pass defense, while the 49ers' run game may find opportunities against the Cardinals' defensive line. Key players like Christian McCaffrey and Nick Bosa for the 49ers, and James Conner and Budda Baker for the Cardinals, will be pivotal.

Broadcast on FOX, this Sunday football matchup is not one to miss. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

How do the Cardinals' and 49ers' records compare?

ATS Records

Arizona

San Francisco

All

All
1st half
2nd half
1st quarter
2nd quarter
3rd quarter
4th quarter

1-1 (16th)Against the Spread2-0 (6th)

2-0 (2nd)Straight Up2-0 (9th)

+0.6Straight Up Units+1.4

1-1Over / Under1-1

TEAM MATCHUP

Arizona

San Francisco

OFF

DEF

OFF

DEF

23.5Points21.5

18.5First Half11.5

5Second Half10

6.5First Quarter6.5

12Second Quarter5

5Third Quarter1.5

0Fourth Quarter8.5

284.5Total Yards364

5.9Yards Per Play5.3

170.5Passing Yards266

19 - 27 (70.4%)Completions-Attempts26 - 37 (70.3%)

5.7Yards Per Passing Play6.8

3 (21)Sacks (Yards)2 (12)

114Rushing Yards98

24.5Attempts31

4.7Yards Per Rush3.2

17.51st Downs23.5

10.5Passing15

5Rushing6

2Penalties2.5

4.5 / 11 (40.9%)3rd Down7.5 / 14.5 (51.7%)

0.5 / 0.5 (100%)4th Down1 / 1 (100%)

2 / 3.5 (57.1%)Red Zone2 / 3.5 (57.1%)

10.5 (75)Penalties (Yards)7 (50.5)

0.5Turnovers0.5

0.5Interceptions-

0Fumbles Lost0.5

51.5Total Plays68

5.5Kickoffs5

3.5Returns2

80Return Yards43.5

22.9Yards Per Return21.8

3Punts3

2Returns2.5

29.5Return Yards20

14.8Yards Per Return8

Priority Injuries

Arizona

San Francisco

No priority injuries for this team

PRIORITY

Brock Purdy

Questionable

Est. Return Sep 21, 2025

13 Quarterback

10 hours ago

PRIORITY

George Kittle

Injury Reserve

Est. Return Oct 12, 2025

85 Tight End

10 days ago

HEAD TO HEAD

Arizona

ARI

San Francisco

NFL

ODDS PICKS PLAYER PROPS FUTURES PLAYER FUTURES INJURIES WEATHER RANKINGS STANDINGS

Spread

Spread
Money
Total
Merged

Game

Game
1H
2H
1Q
2Q
3Q
4Q

This Week

Last Week

Personalize your notifications and get updates on the teams, players or events you care about most. SUN 09/211:00 PM Indianapolis 2-0 26% -3½ -115BetMGM
Tennessee 0-2 74% +4½ -118FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 09/211:00 PM Atlanta 1-1 20% -5½ -105Caesars
Carolina 0-2 80% +5½ -109BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 09/211:00 PM Las Vegas 1-1 67% +3½ -113BetRivers
Washington 1-1 33% -3½ +100Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 09/211:00 PM Green Bay 2-0 23% -7½ -110Caesars
Cleveland 0-2 77% +8 -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 09/211:00 PM Cincinnati 2-0 53% +3 -112Caesars
Minnesota 1-1 47% -2½ -130BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 09/211:00 PM L.A. Rams 2-0 56% +3½ -115BetMGM
Philadelphia 2-0 44% -3 -125Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 09/211:00 PM Pittsburgh 1-1 36% -1½ -108FanDuel
New England 1-1 64% +1½ -105Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 09/211:00 PM N.Y. Jets 0-2 82% +7 -120BetMGM
Tampa Bay 2-0 18% -6½ -110FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 09/211:00 PM Houston 0-2 38% +1½ -108FanDuel
Jacksonville 1-1 62% -1½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 09/214:05 PM Denver 1-1 71% +3 -120Caesars
L.A. Chargers 2-0 29% -2½ -114BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 09/214:05 PM New Orleans 0-2 77% +7½ -110BetMGM
Seattle 1-1 23% -7½ -105Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 09/214:25 PM Dallas 1-1 19% -½ -110BetRivers
Chicago 0-2 81% +1½ -115FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 09/214:25 PM Arizona 2-0 53% +2½ +100Caesars
San Francisco 2-0 47% -2½ -110BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 09/218:20 PM Kansas City 0-2 21% -5½ -120FanDuel
N.Y. Giants 0-2 79% +6½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. MON 09/228:15 PM Detroit 1-1 70% +5½ -115FanDuel
Baltimore 1-1 30% -4½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTHU 09/188:15 PM Miami 0-3 21 +12 -110BetRivers
Buffalo 3-0 31 -11 -110Bet365

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Arizona Cardinals vs San Francisco 49ers Betting Trends

ATS Records

Arizona

San Francisco

TEAM MATCHUP

Arizona

San Francisco

Priority Injuries

Arizona

San Francisco

Recent Results

Arizona

San Francisco

HEAD TO HEAD

Arizona

San Francisco

Arizona

UPCOMING SCHEDULE

San Francisco