Player Props Carolina Panthers vs San Francisco 49ers

The Monday night football showdown on November 24, 2025, between the Carolina Panthers and San Francisco 49ers at Levi's Stadium in Santa Clara, CA, is set to be a thrilling NFL regular-season game. This matchup offers excellent player props betting opportunities, especially given the contrasting styles and strengths of both teams. The 49ers' pass offense will be tested against the Panthers' pass defense, while Carolina's run offense faces a tough San Francisco run defense. Add to that the battle between the 49ers' pass protection and Carolina's pass rush, and bettors have plenty to consider.

Our player props predictions favor Christian McCaffrey's rushing attempts under 17.5 with a 59.9% hit rate and a positive EV of 7.1%, making it a strong prop bet to consider. On the other side, Bryce Young's passing yards over 200.5 show a 55.7% hit rate and a 2.4% EV, signaling potential value for bettors. These insights are backed by our player projections, which have performed well over the last 10 games, maintaining profitable returns for bettors.

Watching the game on ESPN, fans can expect a strategic contest where passing yards and rushing yards will be crucial factors influencing the outcome and the player props markets. The pace of play suggests opportunities for both rushing and passing props, helping bettors make informed decisions. For a deeper dive into player props for the NFL, check out our comprehensive NFL player props page. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.