- Spread
- Money
- Total
- Merged
Personalize your notifications and get updates on the teams, players or events you care about most.
Nov 24, 2025 8:15 PM EST
Week 12
SF
-7 (-110)o49 (-110)
ESPN, 206MATCHUP
PREDICTION
ODDS
BOOSTS
PLAYER PROPS
GAME PROPS
INJURIES
WEATHER
CHAT
Event NotificationsStay on top of the action with alerts for game start, scoring, odds updates, predictions and more.
Don't show me this again
Carolina Panthers vs San Francisco 49ers Picks
Updated:Nov 20, 2025 1:24 AM EST
The Monday night football showdown on November 25, 2025, between the Carolina Panthers and San Francisco 49ers at Levi's Stadium in Santa Clara, CA, is set to be a thrilling NFL regular season Week 12 game. Fans can catch the action live on ESPN as these two teams battle it out. Our expert picks favor the 49ers to win with a predicted score of 27-21, covering the spread at -6.5. The total points are expected to stay just under 49, with a predicted total score of 48.16.
Our prediction model has been profitable in recent games, especially in the point spread market where the Panthers have covered 5 of their last 10 spreads, and the 49ers have covered 6 of their last 10. The under 49 total market also shows a solid hit rate of 51.9% and a small negative EV, indicating a smart betting edge for totals under 49 points in this matchup. These stats provide valuable betting tips to help bettors make informed wagers.
For those looking to sharpen their betting strategy, our NFL picks and predictions offer an edge. Dive deeper into expert analysis and place your bets confidently with a U.S. regulated sportsbook or start your OddsTrader Turbo subscription to maximize your profits.
UPCOMING GAME PREDICTION
Spread
Money
Total
CARSpread
CONSENSUS LINE
+7 (-110)
PROJECTION
SF (27) - CAR (21)
COVER PROBABILITY
EXPECTED VALUE
-0.6%
BET RATING
SEASON COVER %
7/11
64%
OTHER BETS
Mon 11/24 8:15 PMCAR @ SF
Brock PurdyPlayer Longest Passing Completion
UNLOCK
Bryce YoungPlayer to score first touchdown
EV
+17.6%
+17.6%
Kyle JuszczykPlayer to score first touchdown
EV
+17.4%
+17.4%
Tommy TremblePlayer to score first touchdown
EV
+17.2%
+17.2%
Bryce YoungPlayer Longest Passing Completion
EV
+12.8%
+12.8%
Luke FarrellPlayer to score first touchdown
EV
+10.9%
+10.9%
Hunter RenfrowAnytime Touchdown Scorer
EV
+9.9%
+9.9%
Christian McCaffreyPlayer Longest Reception
EV
+9.8%
+9.8%
Brock PurdyPlayer to score first touchdown
EV
+8.9%
+8.9%
Christian McCaffreyReceiving Yards
EV
+7.6%
+7.6%
NFL
Spread
Game
- Game
- 1H
- 2H
- 1Q
- 2Q
- 3Q
- 4Q
This Week
Last Week
NFLWeek 12
 Houston 5-572% +6 -109Caesars | |||||||
 Chicago 7-356% -2½ -114Caesars | |||||||
 Baltimore 5-516% -13½ -108Caesars | |||||||
 Detroit 6-45% -10½ -102FanDuel | |||||||
 Cincinnati 3-772% +7½ -110Bet365 | |||||||
 Tennessee 1-984% +13½ -110BetMGM | |||||||
 Green Bay 6-3-117% -6½ -109Caesars | |||||||
 Kansas City 5-527% -3½ -102BetMGM | |||||||
 Arizona 3-757% +3 -110Caesars | |||||||
 Las Vegas 2-862% -3½ -118FanDuel | |||||||
 New Orleans 2-867% +1 -115Bet365 | |||||||
 Dallas 4-5-154% +3½ -115BetMGM | |||||||
 L.A. Rams 8-236% -6½ -110Bet365 | |||||||
 San Francisco 7-49% -6½ -115Bet365 |
Download the app© OddsTrader 2025 All Rights Reserved
The content on this site is for entertainment purposes only. OddsTrader makes no representation or warranty as to the accuracy of the information given or the outcome of any game or event. Please be aware of and respect the laws regarding sports betting for your jurisdiction as they vary from state to state. OddsTrader does not target underaged persons. Using this information to contravene any law or statute is prohibited. This site contains commercial content, and OddsTrader may be compensated for the links provided on this site.Disclosure.
OddsTrader is licensed to operate in NJ, NY, PA, IN, CO, IA, IL, VA, WV, TN, CT, MI, AZ, LA, WY, OR, KS, DC, MA & OH.
Seek help with a gambling addiction at 1-800-Gambler.
OddsTrader uses cookies to help us provide, protect & improve our services. See ourPrivacy Policyfor more details.
ACCEPT & CLOSE