Carolina Panthers vs San Francisco 49ers Game Props

The Monday night football showdown on November 24, 2025, between the Carolina Panthers and San Francisco 49ers at Levi's Stadium in Santa Clara, CA, sets the stage for an exciting NFL Week 12 clash. This game features a compelling matchup of pass offense versus pass defense and run offense against run defense, with the 49ers' solid pass protection facing the Panthers' aggressive pass rush. Bettors looking into game props will find valuable opportunities here, especially considering the high hit rate and EV of the "Player to score first touchdown" prop, where Christian McCaffrey stands out as a favorite.

Both teams bring dynamic offenses, but the 49ers' home advantage and strong defensive play could sway totals and prop bets. Our projections have been successful in the past 10 games, particularly in the player props market, giving bettors an edge when wagering on touchdowns and field goals. The pace of play suggests a balanced offensive approach, which can influence the totals and team props markets.

Watch the game live on ESPN and take advantage of our insights to make smart betting decisions. For more detailed player prop bets and expert picks, visit our NFL player props page and NFL picks page. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.